BODY-WEIGHT VERSUS BODY-FAT DISTRIBUTION, ADIPOSITY, AND FRAME SIZE AS PREDICTORS OF BONE-DENSITY
BODY-WEIGHT VERSUS BODY-FAT DISTRIBUTION, ADIPOSITY, AND FRAME SIZE AS PREDICTORS OF BONE-DENSITY
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DOI：
10.1210/jc.80.4.1118
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发表时间：
1995-04-01
影响因子：
5.8
通讯作者：
ORWOLL, ES
中科院分区：
文献类型：
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作者：
GLAUBER, HS;VOLLMER, WM;ORWOLL, ES
体重与骨密度(BMD)密切相关，但这种影响的机制尚不清楚。对6705名参与骨质疏松性骨折研究的老年妇女进行了体重、身高、腰臀比、肘宽、肥胖和骨密度的测量。用生物电阻抗法测量肥胖程度，用单光子(桡骨和跟骨近、远端)和双能X线骨密度仪(腰椎和股骨近端)测量骨密度。年龄调整后的体重和骨密度之间的相关性在所有部位都很强(R(2)=5.9-20.4%)，但将其他人体测量学变量添加到模型中只略微改善了这种相关性。肥胖在很大程度上解释了体重对BMD的影响，特别是在承重部位(36-62%)。另一方面，体重几乎解释了肥胖对承重部位骨密度的所有变异性(81%-100%)。在放射状测量部位，肥胖症有更重要的独立贡献。体重似乎不影响BMD与年龄的关系。总而言之，在负重部位，体重对BMD的影响主要是质量效应的直接结果，而不是肥胖，而在非负重部位，肥胖发挥着更重要的影响，可能是由代谢因素介导的。
Weight is strongly associated with bone mineral density (BMD), but the mechanism of this effect is not well understood. Weight, height, hip-waist ratio, elbow breadth, adiposity, and BMD were measured in 6705 older women participating in the Study of Osteoporotic Fractures. Adiposity was measured by bioelectric impedance and BMD by single-photon (proximal and distal radius and calcaneus) and dual-energy x-ray absorptiometry (lumbar spine and proximal femur). Age-adjusted associations between weight and BMD were robust at all sites (R(2) = 5.9-20.4%), but the addition of other anthropometric variables to the model only marginally improved the association. Adiposity explained a substantial fraction of the effect of weight on BMD, particularly at weight-bearing sites (36-62%). On the other hand, weight explained virtually all the variability of adiposity on BMD at weight-bearing sites (81-100%). At the radial measurement sites, adiposity had more substantial independent contributions. Weight did not seem to influence the relationship between BMD and age. In sum, at weight bearing-sites, the preponderance of the effect of weight on BMD is a direct result of mass effects rather than adiposity, whereas at non-weight-bearing sites, adiposity exerts more important effects, potentially mediated by metabolic factors.