Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope.
Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope.
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DOI：
10.1002/hed.21735
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发表时间：
2012-03
影响因子：
2.9
通讯作者：
Gillenwater, Ann M.
中科院分区：
文献类型：
--
作者：
Muldoon, Timothy J.;Roblyer, Darren;Williams, Michelle D.;Stepanek, Vanda M. T.;Richards-Kortum, Rebecca;Gillenwater, Ann M.
本研究的目的是评估高分辨率显微内窥镜成像和量化早期口腔肿瘤细胞和结构特征变化的能力。高分辨率显微内窥镜（HRME）用于成像完整的，切除的口腔鳞癌标本。由专家临床医生审查HRME图像并将其分类为非肿瘤性或肿瘤性。基于定量形态学特征的算法也被用来分类每个图像。结果进行了比较，组织病理学诊断。HRME图像来自13例患者的141个部位的切除标本。主观图像判读的敏感性和特异性分别为85%至90%和80%至85%，而客观分类算法的敏感性和特异性分别为81%和77%。完整口腔粘膜的高分辨率显微内窥镜检查可以提供足够详细的图像，通过主观图像解释和客观图像分析对口腔病变进行分类。© 2011 Wiley Periodicals，Inc.头颈部，2011年
The purpose of this study was to evaluate the ability of high-resolution microendoscopy to image and quantify changes in cellular and architectural features seen in early oral neoplasia in vivo. A high-resolution microendoscope (HRME) was used to image intact, resected oral squamous carcinoma specimens. HRME images were reviewed and classified as non-neoplastic or neoplastic by expert clinicians. An algorithm based on quantitative morphologic features was also used to classify each image. Results were compared to the histopathologic diagnosis. HRME images were obtained from 141 sites in resected specimens from 13 patients. Subjective image interpretation yielded sensitivity and specificity of 85% to 90% and 80% to 85%, respectively, whereas the objective classification algorithm achieved sensitivity and specificity of 81% and 77%, respectively. High-resolution microendoscopy of intact oral mucosa can provide images with sufficient detail to classify oral lesions by both subjective image interpretation and objective image analysis. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
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DOI：
10.1016/0002-9378(78)90713-5
发表时间：
1978-01-01
影响因子：
9.8
作者：
KAUFMAN, RH;ADAM, E;YOUNG, RL
通讯作者：
YOUNG, RL
影响因子：
12.6
作者：
Kiesslich, Ralf;Gossner, Liebwin;Neurath, Markus F.
通讯作者：
Neurath, Markus F.
影响因子：
1.4
作者：
ANDREA, M;DIAS, O;SANTOS, A
通讯作者：
SANTOS, A
影响因子：
8
作者：
Janssen, PA;Selwood, BL;Thiessen, PN
通讯作者：
Thiessen, PN
影响因子：
3.5
作者：
Collier, Tom;Guillaud, Martial;Richards-Kortum, Rebecca
通讯作者：
Richards-Kortum, Rebecca