Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis.
Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis.
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DOI：
10.2340/00015555-2408
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发表时间：
2016-08-23
影响因子：
3.6
通讯作者：
Sigurgeirsson B
中科院分区：
文献类型：
--
作者：
Thorleifsdottir RH;Eysteinsdóttir JH;Olafsson JH;Sigurdsson MI;Johnston A;Valdimarsson H;Sigurgeirsson B
链球菌咽喉感染是已知的触发或加重银屑病，和几项研究支持扁桃体切除术的好处。为了评估扁桃体切除术作为治疗的潜力，我们使用了一项回顾性研究特定的问卷调查，以评估银屑病患者咽喉痛相关的银屑病恶化的比例。我们调查了275例银屑病患者。42%的斑块状银屑病患者报告了咽喉痛相关的银屑病加重，72%的确诊链球菌感染患者报告了加重。值得注意的是，女性和早发性银屑病患者更可能在咽喉痛后报告银屑病恶化（分别为p<0.001，p=0.046）。其他银屑病加重因素在咽喉痛相关加重患者中更常见（p<0.01）。49%的扁桃体切除术患者报告了随后的改善，并且与扁桃体切除术后没有改善的患者相比，更频繁地出现与银屑病加重相关的咽喉痛（p=0.015）。这些研究结果表明，喉咙痛，链球菌咽喉感染和斑块状银屑病之间的联系比以前报道的更密切。
Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Our survey sampled 275 psoriasis patients. 42% of patients with plaque psoriasis reported sore throat-associated psoriasis exacerbations, and 72% of patients with confirmed streptococcal infections reported aggravation. Notably, women and early onset psoriasis patients were more likely to report psoriasis exacerbation after a sore throat (p<0.001, p=0.046 respectively). Other psoriasis aggravation factors were more common in patients with sore throat-associated exacerbations (p<0.01). 49% of tonsillectomized patients reported subsequent improvement and had more frequent sore throat-associated aggravation of psoriasis than patients who did not improve after tonsillectomy (p=0.015). These findings suggest a closer association between sore throats, streptococcal throat infections and plaque psoriasis than previously reported.