VEGF-C is associated with lymphatic status and invasion in oral cancer
VEGF-C is associated with lymphatic status and invasion in oral cancer
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DOI：
10.1136/jcp.2007.047662
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发表时间：
2008-01-01
影响因子：
3.4
通讯作者：
Takata, T.
中科院分区：
文献类型：
--
作者：
Siriwardena, B. S. M. S.;Kudo, Y.;Takata, T.
背景：淋巴结转移是口腔鳞状细胞癌（OSCC）进展的主要预后指标。最近研究表明，淋巴管生长因子VEGF-C及其受体Flt-4在癌细胞的侵袭和转移中发挥重要作用。目的：研究VEGF-C的表达及其与淋巴管状态的相关性，包括淋巴管数量和淋巴管侵袭、肿瘤侵袭和转移。方法：应用D2-40法检测54例口腔鳞癌的瘤内和瘤周淋巴管，并与VEGF-C表达和临床病理结果进行相关性分析。结果：VEGF-C在口腔鳞癌组织中高表达，与淋巴管数目增多、淋巴管浸润密切相关。结论：VEGF-C在口腔鳞癌的转移过程中可能与淋巴管生成和浸润密切相关，可作为口腔鳞癌转移的预测因子。
Background: Nodal metastasis is a major prognostic indicator for oral squamous cell carcinoma (OSCC) progression. Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and metastasis in cancer cells.Aim: To examine VEGF-C expression and its correlation with lymphatic status, including the number of lymph vessels and lymphatic invasion, tumour invasion and metastasis in OSCC.Methods: Intratumoural and peritumoural lymphatic vessels were examined using D2-40 in 54 OSCC cases and correlated with VEGF-C expression and clinicopathological findings. The histological pattern of invasion and pathological findings were compared.Results: High expression of VEGF-C was frequently observed in OSCC and was associated with increased number of lymph vessels and lymphatic invasion. VEGF-C was well correlated with invasion pattern and metastasis.Conclusions: Results suggest that VEGF-C may play an important role for lymphangiogenesis and invasion in the metastatic process and can be a strong predicting factor for metastasis of OSCC.