AGE-ASSOCIATED CHANGES OF PITUITARY-ADRENOCORTICAL HORMONE REGULATION IN HUMANS - IMPORTANCE OF GENDER
AGE-ASSOCIATED CHANGES OF PITUITARY-ADRENOCORTICAL HORMONE REGULATION IN HUMANS - IMPORTANCE OF GENDER
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DOI：
10.1016/0197-4580(94)90117-1
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发表时间：
1994-03-01
影响因子：
4.2
通讯作者：
HOLSBOER, F
中科院分区：
文献类型：
--
作者：
HEUSER, IJ;GOTTHARDT, U;HOLSBOER, F
在本研究中的假设进行了测试，在正常的人类衰老的糖皮质激素反馈信号的不敏感性被收购。因此，40名健康老年人（平均年龄：69 +/- 5岁）和20名年轻人（平均年龄：34 +/- 8岁）进行了联合地塞米松抑制/CRH刺激试验，老年组在地塞米松（DEX）预处理后和CRH前皮质醇分泌增加，但没有一名受试者逃脱DEX诱导的皮质醇抑制。然而，在对DEX预处理的志愿者进行额外的CRH给药后，老年组释放的皮质醇明显多于年轻组。在组内的老年人，正相关的基础，DEX预处理的皮质醇浓度和后CRH类固醇responses被发现。性别深刻影响DEX/CRH测试结果：女性，无论年龄大小，有增加的激素分泌相比，男性。它的结论是，在人类衰老过程中，糖皮质激素受体发生适应性变化，允许系统保持“外周”糖皮质激素的稳态，但更复杂的挑战程序，如DEX/CRH测试揭示了年龄相关的HPA系统活性增加。
In the present study the hypothesis was tested that in normal human aging an insensitivity of the glucocorticoid feedback signal is acquired. Thus, 40 healthy elderly (mean age: 69 +/- 5 years) and 20 younger (mean age: 34 +/- 8 years) individuals underwent a combined dexamethasone suppression/CRH-stimulation test.Cortisol secretion after dexamethasone (DEX) pretreatment and before CRH was increased in the older age group, but none of the subjects escaped DEX-induced suppression of cortisol. However, after additional CRH administration to the DEX-pretreated volunteers, the older group released significantly more cortisol than their young counterparts. Within the group of the elderly only, a positive correlation between BASAL, DEX-pretreated cortisol concentration and post-CRH steroid responses was found. Gender profoundly affected DEX/CRH-test outcome: females, regardless of age, had an increased hormonal secretion in comparison to males. It is concluded that, during human aging, adaptive changes in glucocorticoid receptors take place, allowing for the system to maintain ''peripheral'' glucocorticoid homeostasis, but that more sophisticated challenge procedures such as the DEX/CRH test reveal an age-related increase in HPA system activity.