Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): A review on its pharmacology, molecular mechanism, and structural modification
Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): A review on its pharmacology, molecular mechanism, and structural modification
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DOI：
10.1016/j.phytochem.2022.113247
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yan-Ling Wu
中科院分区：
文献类型：
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作者：
Jia-Yi Dou;Yu-Chen Jiang;Zhen-Yu Cui;Li-Hua Lian;Ji-Xing Nan;Yan-Ling Wu
Acanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-diabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nuclear factor-kappa B (NF-κB), Toll-Like Receptor 4 (TLR4) and IL-1 receptor-associated kinase (IRAK) signaling pathways, or AMP-activated protein kinase (AMPK) signaling pathway, etc. Also, some studies focus on the structural modification of AA to improve its pharmacological activities. The review summarizes the pharmacological activities, molecular mechanism, and the structural modification of AA, which might supply information for the development of AA in the future. • Acanthoic Acid is active ingredient from Acanthopanax koreanum Nakai (Araliaceae). • A Review on the pharmacology, molecular mechanism, and structural modification of AA. • Provide experimental and theoretical basis for the research of AA and its derivatives. • Benefit for the development of new drugs based on Acanthoic acid.
