IP3 RECEPTOR - LOCALIZATION TO PLASMA-MEMBRANE OF T-CELLS AND COCAPPING WITH THE T-CELL RECEPTOR
IP3 RECEPTOR - LOCALIZATION TO PLASMA-MEMBRANE OF T-CELLS AND COCAPPING WITH THE T-CELL RECEPTOR
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DOI：
10.1126/science.1323146
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发表时间：
1992-08-07
期刊：
影响因子：
56.9
通讯作者：
SNYDER, SH
中科院分区：
文献类型：
--
作者：
KHAN, AA;STEINER, JP;SNYDER, SH
淋巴细胞的免疫反应需要细胞外来源的大量钙（Ca2+）的细胞积累。在T细胞肿瘤细胞系Jurkat中，Ca2+释放信使肌醇1,4,5-三磷酸（IP3）的受体定位于质膜（PM）。T细胞受体- cd3复合物的Capping与信号转导相关，同时伴随着IP3受体的Capping。T细胞上的IP3受体似乎负责Ca2+的进入，从而引发增殖反应。
Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca2+-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.