Electrochemical activity of new ferrocene-labelled PNA monomers to be applied for DNA detection: Effects of the molecular structure and of the solvent
Electrochemical activity of new ferrocene-labelled PNA monomers to be applied for DNA detection: Effects of the molecular structure and of the solvent
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DOI：
10.1016/j.jelechem.2005.08.010
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发表时间：
2005-11-15
影响因子：
4.5
通讯作者：
Mussini, PR
中科院分区：
文献类型：
--
作者：
Baldoli, C;Licandro, E;Mussini, PR
肽核酸（PNA）低聚物由于其对DNA具有很强的结合力，是很有前景的DNA探针候选物，但它们通常需要一种合适的电化学或光谱活性标记物。本文描述了两种新合成的、分别用一个或三个活性二茂铁基团衍生化的PNA单体及其前体的系统电化学特性。我们的单体尽管体积较大，但仍显示出较高的电化学活性；此外，我们研究的系统性为分子结构、官能化程度以及工作溶剂对有机金属位点电化学活性的作用提供了有趣的分析。（c）2005爱思唯尔有限公司。保留所有权利。
PNA oligomers are promising candidates as DNA probes on account of their very high DNA binding power, but they generally require an appropriate electrochemically or spectroscopically active marker. This paper describes the systematic electrochemical characterization of two newly synthesized PNA monomers, derivatised with one or three active ferrocene groups, and of their precursors. Our monomers show high electrochemical activity in spite of their bulkiness; moreover, the systematicity of our investigation affords an interesting analysis of the role of the molecular structure, the degree of functionalization and the working solvent on the electrochemical activity of the organometallic site. (c) 2005 Elsevier B.V. All rights reserved.