Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides
Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides
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DOI：
10.1039/c2cc30956d
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Sutherland, Andrew
中科院分区：
文献类型：
--
作者：
Cant, Alastair A.;Bhalla, Rajiv;Sutherland, Andrew
研究了一种快速高效的镍催化芳基溴和杂芳基溴碘化反应。发现这种转化对各种底物都是通用的，并被用于合成碘- pk11195（一种阿尔茨海默病的显像剂）和伊尼帕尼（一种用于治疗乳腺癌的化合物）。
A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer's disease and iniparib, a compound used in the treatment of breast cancer.