Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants
Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants
复制标题
DOI：
10.1542/peds.112.4.773
复制
发表时间：
2003-10-01
期刊：
影响因子：
8
通讯作者：
Wright, LL
中科院分区：
文献类型：
--
作者：
Oh, W;Tyson, JE;Wright, LL
目标。目的探讨极低出生体重儿(ELBW)生后2周血清总胆红素(PSB)峰值水平与绝经后18~22个月神经发育结局的关系。对1994年1月1日至1997年12月31日在美国国家儿童健康与人类发育研究所新生儿研究网络的12个参与中心中存活到14日龄的低出生体重儿(401-1000g)进行了回顾性分析。以18-22个月月经后死亡或不良神经发育结局为参照，对前14天的人口统计学、临床危险因素和PSB水平进行分析。考虑的神经发育变量为精神运动发育指数(PDI)
Objective. To assess the association between peak total serum bilirubin (PSB) levels during the first 2 weeks of life and neurodevelopmental outcomes of extremely low birth weight (ELBW) infants at 18 to 22 months' postmenstrual age.Methods. A retrospective analysis was conducted of a cohort of ELBW infants (401-1000 g) who survived to 14 days of age in the 12 participating centers of the National Institute of Child Health and Human Development Neonatal Research Network between January 1, 1994, and December 31, 1997. Demographic and clinical risk factors and PSB levels during the first 14 days were analyzed with reference to death or adverse neurodevelopmental outcomes at 18 to 22 months' postmenstrual age. The neurodevelopmental variables considered were Psychomotor Developmental Index (PDI)