Transient changes in frontal alpha asymmetry as a measure of emotional and physical distress during sleep
Transient changes in frontal alpha asymmetry as a measure of emotional and physical distress during sleep
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DOI：
10.1016/j.brainres.2010.09.090
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发表时间：
2011-01-07
期刊：
影响因子：
2.9
通讯作者：
Portas, Chiara M.
中科院分区：
文献类型：
--
作者：
Flo, Elisabeth;Steine, Iris;Portas, Chiara M.
该项目的目的是确定与人类在非交流状态下的痛苦经历相关的可测量的生理反应。由于睡眠是一种感觉运动分离的状态，受试者无法报告他们的感受或经历，因此它可以被认为是非交流状态的合适模型。在健康清醒的受试者中，一直有报道称，在健康清醒的受试者中，额叶区域的功率谱α带变化会出现短暂的痛苦相关反应。因此，我们分析了 16 名志愿者在睡眠期间接受痛苦厌恶刺激前后额叶 α 不对称性 (FAA) 的变化。短暂的身体或情绪困扰是通过条件性刺激（电击或情感图像）或直接施加的厌恶刺激（电击）来实现的。还评估了额叶β不对称性（FBA）以进行比较。功率谱数据通过额叶脑电图 (EEG) 导联 (F3/F4) 进行评估。还同时监测皮肤电反应（GSR）和心率（HR）。为了测试短期持续刺激产生长期生理影响的可能性，我们包括唾液皮质醇采样、梦情绪效价评估和睡眠质量测量的标准评估。与中性价刺激相比，不同性质的厌恶刺激在第 2 阶段 (S2) 和快速眼动 (REM) 睡眠中的 FAA（左 > 右）和 GSR 诱发反应中产生可测量的变化，表明负价体验的内隐处理。值得注意的是，梦的内容评估显示出负面情绪增加的趋势。未观察到 FBA，证实了 FAA 响应的特异性。唾液皮质醇和睡眠参数并未受到该方案的显着影响。据我们所知，这是首次在睡眠期间成功应用厌恶性成像调节协议。 (C) 2010 年由 Elsevier B.V. 出版
The aim of this project was to identify measurable physiological responses linked to the human experience of distress in a non-communicative state. Since sleep is a state of sensory-motor detachment in which subjects cannot report how they feel or what they experience, it can be considered a suitable model of non communicative states. A transitory distress-related response has consistently been reported in healthy awake subjects in the form of power spectrum alpha band changes in frontal brain areas. Hence, changes in frontal alpha asymmetry (FAA) were analysed in 16 volunteers before and after administration of distressful aversive stimuli during sleep. Transient physical or emotional distress was achieved by presentation of conditioned (to electroshocks or affective images) or directly-applied aversive stimuli (electroshocks). Frontal beta asymmetry (FBA) was also evaluated for comparisons. Power spectrum data were assessed from frontal electroencephalographic (EEG) leads (F3/F4). Galvanic skin response (GSR) and heart rate (HR) were also simultaneously monitored. To test the possibility that the short lasting stimulations would have long-term physiological effects, we included saliva cortisol sampling, evaluation of dream emotional valence and a standard assessment of sleep quality measurements. Aversive stimulation of diverse nature, compared to neutral valence stimuli, produced measurable changes in FAA (left>right) and in GSR evoked responses in both stage 2 (S2) and rapid eye movement (REM) sleep suggesting implicit processing of experiences with negative valence. Noticeably, dream content evaluation showed a trend towards increased negative emotionality. No FBA was observed, confirming the specificity of FAA responses. Saliva cortisol, and sleep parameters were not significantly affected by the protocol. This is, to our knowledge, the first time that an aversive imaging conditioning protocol has been successfully applied during sleep. (C) 2010 Published by Elsevier B.V.