A COMPARISON OF 2 SIMPLE HAZARD RATIO ESTIMATORS BASED ON THE LOGRANK TEST
A COMPARISON OF 2 SIMPLE HAZARD RATIO ESTIMATORS BASED ON THE LOGRANK TEST
复制标题
DOI：
10.1002/sim.4780100510
复制
发表时间：
1991-05-01
影响因子：
2
通讯作者：
MOCK, PA
中科院分区：
文献类型：
--
作者：
BERRY, G;KITCHIN, RM;MOCK, PA
对两种基于Logrank检验的危险比估计器进行了仿真研究。Pike估计量(相对死亡率的比率)被证明始终比Peto(1步)估计量的偏差小。后者最近被认为是点和区间估计的选择方法。8随着风险比的增加，两种估计器都表现出偏差，尽管对于小于3的影响，偏差是最小的。随着风险比的增加，可信区间也没有达到名义覆盖，但Pike估计仍然更好。可以通过重新计算包含点估计的方差来提高覆盖率。对于小于3的危险比，我们建议使用派克估计器，否则有必要使用更复杂的估计方法。
Two hazard ratio estimators based on the logrank test are investigated using a simulation study. The Pike estimator (ratio of relative death rates) was shown to be consistently less biased than the Peto (1-step) estimator. The latter has recently been advocated as the method of choice for point and interval estimation.8 Both estimators exhibited bias with increasing hazard ratios, although the bias was minimal for effects less than 3. The confidence intervals also did not achieve the nominal coverage with increasing hazard ratios, but again the Pike estimator was superior. The coverage could be improved by recalculation of the variance incorporating the point estimate. For a hazard ratio of less than 3 we recommend the use of the Pike estimator, otherwise it is necessary to use a more complex method of estimation.