Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
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DOI：
10.1016/j.jaci.2004.12.1129
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发表时间：
2005-04-01
影响因子：
14.2
通讯作者：
Israel, E
中科院分区：
文献类型：
--
作者：
Deykin, A;Lazarus, SC;Israel, E
背景：虽然吸入糖皮质激素(ICSS)对预防哮喘控制恶化是有效的，但至少有一半的轻中度哮喘患者在停药后仍能保持稳定。目的：我们试图确定非侵入性炎症标志物是否能预测哪些人在停用ICSS后维持哮喘控制。方法：我们分析了164名参加16周试验的轻中度哮喘患者的数据，比较了继续使用ICS与改用沙美特罗或安慰剂的效果。结果：与继续使用ICS相比，改用沙美特罗或安慰剂与16周后哮喘恶化的发生率增加有关(分别为9.3%vs24.1%和37.5%；P=0.04和P
Background: Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued.Objective: We sought to determine whether noninvasive markers of inflammation predict which individuals maintain asthma control after discontinuation of ICSs.Methods: We analyzed data obtained from 164 subjects with mild-to-moderate asthma who participated in a 16-week trial comparing the effects of continued ICS use with the effects of a switch to salmeterol or placebo.Results: In comparison with continued ICS use, a switch to salmeterol or placebo was associated with increased rates of asthma deterioration over 16 weeks (9.3% vs 24.1% and 37.5%, respectively; P =.04 and P