Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex
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DOI：
10.1111/j.1749-6632.2012.06506.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Paschoud, Serge
中科院分区：
文献类型：
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作者：
Citi, Sandra;Pulimeno, Pamela;Paschoud, Serge
扣带蛋白、副扣带蛋白和PLEKHA 7是定位于脊椎动物上皮细胞的顶端连接复合体的细胞质区域中的蛋白质。已经在紧密连接（TJ）处检测到扣带蛋白，而在TJ和粘附连接（AJs）处都检测到副扣带蛋白，并且已经在AJs处检测到PLEKHA 7。扣带蛋白和副扣带蛋白的一个功能是通过它们与RhoA和Rac 1的胍交换因子的直接相互作用来调节Rho家族GTP酶在连接处的活性。扣带蛋白还有助于调节不同类型培养细胞中几种基因的转录，部分是通过其调节RhoA活性的能力。PLEKHA 7与副胶质蛋白一起是将E-钙粘蛋白连接到AJs微管细胞骨架的蛋白质复合物的一部分。在本文中，我们回顾了目前的知识，这些蛋白质，包括他们的发现，他们的表达，定位，结构，分子相互作用的表征，以及他们在不同的发育和疾病模型系统中的作用。
Cingulin, paracingulin, and PLEKHA7 are proteins localized in the cytoplasmic region of the apical junctional complex of vertebrate epithelial cells. Cingulin has been detected at tight junctions (TJs), whereas paracingulin has been detected at both TJs and adherens junctions (AJs) and PLEKHA7 has been detected at AJs. One function of cingulin and paracingulin is to regulate the activity of Rho family GTPases at junctions through their direct interaction with guanidine exchange factors of RhoA and Rac1. Cingulin also contributes to the regulation of transcription of several genes in different types of cultured cells, in part through its ability to modulate RhoA activity. PLEKHA7, together with paracingulin, is part of a protein complex that links E-cadherin to the microtubule cytoskeleton at AJs. In this paper, we review the current knowledge about these proteins, including their discovery, the characterization of their expression, localization, structure, molecular interactions, and their roles in different developmental and disease model systems.