SMOKING CESSATION, CLONIDINE, AND VULNERABILITY TO NICOTINE AMONG DEPENDENT SMOKERS
SMOKING CESSATION, CLONIDINE, AND VULNERABILITY TO NICOTINE AMONG DEPENDENT SMOKERS
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DOI：
10.1038/clpt.1993.205
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发表时间：
1993-12-01
影响因子：
6.7
通讯作者：
COOPER, TB
中科院分区：
文献类型：
--
作者：
GLASSMAN, AH;COVEY, LS;COOPER, TB
目的：本研究探讨可乐定戒烟的疗效和性别的影响，抑郁症的历史，尼古丁dependence.Methods的措施：这项研究被设计为一个为期10周的双盲随机比较分层的性别和抑郁症。300名严重吸烟的受试者入组研究。戒烟情况通过自我报告进行评估，并通过血清可替宁水平进行验证。结果：性别、抑郁症复发类型和尼古丁成瘾程度是治疗失败的危险因素。有没有可乐定的影响，在男性，但有一个温和的影响，在妇女（比值比，2.01; 95%置信区间，1.00至4.10），是最明显的（比值比，8.5; 95%置信区间，1.67至43.62）的妇女与最高的risks.Conclusion：成瘾和抑郁症的措施预测治疗失败。它们一起是比药物更强的结果预测因子。可乐定对戒烟的帮助有限，药物作用主要来自治疗失败的高风险女性。在有抑郁症病史的吸烟者中，尤其是双相情感障碍患者，戒烟后精神并发症的风险明显增加。
Objective: This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence.Methods: The study was designed as a 10-week double-blind randomized comparison stratified for gender and major depression. Three hundred subjects who smoked cigarettes heavily were enrolled in the study. Abstinence from smoking was evaluated by self-report and verified by serum cotinine levels.Results: Gender, major depression recurrent type, and measures of nicotine addiction were risk factors for treatment failure. There was no clonidine effect in men, but there was a modest effect in women (odds ratio, 2.01; 95% confidence interval, 1.00 to 4.10) that was most pronounced (odds ratio, 8.5; 95% confidence interval, 1.67 to 43.62) among women with the highest risks.Conclusion: Measures of addiction and major depression predict treatment failure. Together they are stronger predictors of outcome than drug. Clonidine is a limited aid in cessation, and drug effects come primarily from women at high risk for treatment failure. An increased risk for psychiatric complications after smoking cessation was apparent among smokers with histories of major depression, particularly bipolar disease.