Antibacterial supramolecular polymers constructed via self-sorting: promoting antibacterial performance and controllable degradation
Antibacterial supramolecular polymers constructed via self-sorting: promoting antibacterial performance and controllable degradation
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自排序构建抗菌超分子聚合物：提升抗菌性能并可控降解
DOI：
10.1039/c9qm00028c
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发表时间：
2019-05-01
影响因子：
7
通讯作者：
Zhang, Xi
中科院分区：
文献类型：
--
作者：
Yang, Yuchong;Hu, Hao;Zhang, Xi
开发了一种抗菌超分子聚合物，它具有增强的抗菌效果和可控的降解性。为此，我们合成了一种含有两个萘基和一个苯基的水溶性双功能单体，以及一个具有抗菌活性的小分子。通过双官能团单体、小分子抗菌剂和瓜环的自分类，制备了侧链抗菌超分子聚合物。对氨苄西林耐药的大肠埃希菌表现出较强的抗菌活性，这主要是由于其局部浓缩作用。抗菌超分子聚合物的受控降解可以很好地调节其抗菌性能从高活性到低活性。预计这一研究路线可能会导致新的抗菌超分子材料，以构建具有增强抗菌效果的可降解抗生素，以对抗耐药细菌。
An antibacterial supramolecular polymer is developed that exhibits enhanced antibacterial efficacy and controlled degradability. To this end, a water-soluble bifunctional monomer bearing two naphthalene moieties and a phenylbenzene moiety, as well as a small molecule with antibacterial activity were synthesized. The side-chain antibacterial supramolecular polymer was fabricated through self-sorting of the bifunctional monomer, the small-molecule antibacterial agent, and cucurbit[8]uril. It displayed enhanced antibacterial efficacy against ampicillin-resistant E. coli owing to the local enrichment effect. The controlled degradation of the antibacterial supramolecular polymer could well regulate its antibacterial performance from high to low activity. It is anticipated that this line of research may lead to novel antibacterial supramolecular materials for building degradable antibiotics with enhanced antibacterial efficacy to fight against drug-resistant bacteria.