ACETYL-DERIVATIVES AS INTERMEDIATES IN POLYAMINE CATABOLISM
ACETYL-DERIVATIVES AS INTERMEDIATES IN POLYAMINE CATABOLISM
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DOI：
10.1016/0020-711x(81)90080-x
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
SEILER, N
中科院分区：
文献类型：
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作者：
BOLKENIUS, FN;SEILER, N
1N-乙酰精胺、1N-乙酰精胺和1N,12N-二乙酰精胺比精胺和亚精胺具有更低的Km和更高的Vmax值，并且是比非乙酰化多胺更好的[大鼠肝脏]多胺氧化酶底物。多胺氧化酶将这些乙酰基衍生物分别分解为3-乙酰氨基丙醛、腐胺和亚精胺。因此，多胺的乙酰化和随后的氧化必须被认为是这些化合物的主要分解代谢命运。先前描述的脱乙酰化和排泄以及乙酰化多胺的氧化降解被认为是与多胺功能密切相关的重要代谢反应。
1N-acetylspermidine, 1N-acetylspermine and 1N,12N-diacetylspermine have lower Km and higher Vmax values than spermine and spermidine and are better substrates of [rat liver] polyamine oxidase than the non-acetylated polyamines. Polyamine oxidase splits these acetylderivatives to 3-acetamidopropanal and putrescine and spermidine, respectively. Thus, the acetylation and subsequent oxidation of the polyamines must be considered to be a major catabolic fate of these compounds. previously described deacetylation and excretion together with oxidative degradation of acetylated polyamines are presumed to be vital metabolic reactions intimately involved in polyamine functions.