Sleep, Positive Affect, and Circulating Interleukin-6 in Women With Temporomandibular Joint Disorder.
Sleep, Positive Affect, and Circulating Interleukin-6 in Women With Temporomandibular Joint Disorder.
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DOI：
10.1097/psy.0000000000001047
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发表时间：
2022-04-01
影响因子：
3.3
通讯作者：
Finan PH
中科院分区：
文献类型：
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作者：
Hunt CA;Mun CJ;Owens MA;Lerman SF;Kunatharaju S;Tennen HA;Buenaver LF;Campbell CM;Haythornthwaite JA;Smith MT;Finan PH
全身性炎症通常在特发性慢性疼痛病症中观察到，包括颞下颌关节紊乱病（TMD）。在健康对照组中，特质积极影响（PA）与较低的炎症相关，但这些影响可能受到睡眠不足的威胁。PA与促炎细胞因子活性和睡眠对慢性疼痛的潜在调节之间的关联尚不清楚。因此，我们调查PA和循环白细胞介素-6（IL-6）之间的关联，并在TMD和睡眠困难的女性样本中通过睡眠调节这种关联。参与者（n = 110）完成了失眠严重程度指数，并在整个诱发疼痛测试过程中以5个间隔提供血液样本。然后，他们完成了为期14天的日记，评估睡眠和情感，沿着手腕活动记录仪。PA对静息或疼痛诱发的IL-6没有显著的主效应（B = 0.04，p = 0.33）。日记总睡眠时间（TST; B =-0.002，p = .008），睡眠效率（SE; B = −0.01，p = 0.005），睡眠起始潜伏期（SOL; B = 0.006，p = 0.010）和入睡后觉醒（WASO; B = 0.003，p = 0.033）与PA相互作用预测IL-6，因此PA在较高水平的TST和SE以及较低水平的SOL和WASO下反向预测IL-6。令人惊讶的是，当睡眠不佳时，PA预测IL-6更高。PA对静息IL-6的潜在有益作用在睡眠不足时侵蚀，强调了在TMD的概念和干预模型中考虑睡眠的重要性。
Systemic inflammation is commonly observed in idiopathic chronic pain conditions, including temporomandibular joint disorder (TMD). Trait positive affect (PA) is associated with lower inflammation in healthy controls, but those effects may be threatened by poor sleep. The associations between PA with proinflammatory cytokine activity and potential moderation by sleep in chronic pain are not known. We thus investigated the association between PA and circulating interleukin-6 (IL-6) and moderation of that association by sleep in a sample of women with TMD and sleep difficulties. Participants (n = 110) completed the insomnia severity index and provided blood samples at 5 intervals throughout an evoked pain testing session. They then completed a 14-day diary assessing sleep and affect, along with wrist actigraphy. There was not a significant main effect of PA on resting or pain-evoked IL-6 (b = 0.04, p = 0.33). Diary total sleep time (TST; b = −0.002, p = .008), sleep efficiency (SE; b = −0.01, p = .005), sleep onset latency (SOL; b = 0.006, p = .010) and wake after sleep onset (WASO; b = 0.003, p = .033) interacted with PA to predict IL-6, such that PA inversely predicted IL-6 at higher levels of TST and SE and at lower levels of SOL and WASO. Surprisingly, when sleep was poor, PA predicted greater IL-6. The potential salutary effects of PA on resting IL-6 erode when sleep is poor, underscoring the importance of considering sleep in conceptual and intervention models of TMD.