POSTPARTUM CHANGES IN THE MINIMUM ALVEOLAR CONCENTRATION OF ISOFLURANE
POSTPARTUM CHANGES IN THE MINIMUM ALVEOLAR CONCENTRATION OF ISOFLURANE
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DOI：
10.1097/00000542-199506000-00006
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发表时间：
1995-06-01
期刊：
影响因子：
8.8
通讯作者：
GIN, T
中科院分区：
文献类型：
--
作者：
CHAN, MTV;GIN, T
背景：最低肺泡浓度(MAC)在妊娠期间降低，但尚不清楚分娩后MAC多快恢复正常。方法：选择分娩后行输卵管结扎术的妇女20例，采用异氟醚吸入麻醉诱导并气管插管。通过观察不同浓度异氟醚对10-S、50-HZ、80-mA经皮尺神经强直电刺激的反应，确定每个患者的MAC。在每次刺激前，异氟醚的呼气末浓度保持至少10分钟不变，并且异氟醚的浓度最终以0.05vol%的步长变化，直到我们得到一系列三个交替的反应：移动-不移动-移动或不移动-移动-不移动，每个受试者的MAC被认为是仅允许移动和仅阻止移动的两种浓度的平均值。麻醉诱导前立即采静脉血测定孕酮浓度。结果：产后MAC与产后时间呈正相关(P<0.05)，与孕酮呈正相关(P
Background: Minimum alveolar concentration (MAC) is decreased in pregnancy, but it is not known how quickly after delivery MAC returns to normal. We measured the MAC of isoflurane in a group of women undergoing elective tubal ligation after delivery.Methods: After delivery, 20 patients underwent inhalational induction of anesthesia with isoflurane and tracheal intubation. MAC was determined in each patient by observing the response to a 10-s, 50-Hz, 80-mA transcutaneous tetanic electric stimulus to the ulnar nerve at various concentrations of isoflurane. The end-tidal concentration of Isoflurane was kept constant for at least 10 min before each stimulus, and the concentration of isoflurane was ultimately varied in steps of 0.05 vol%until we obtained a sequence of three alternate responses: move-not move-move or not move-move-not move, The MAC for each subject was taken as the mean of the two concentrations just permitting and just preventing movement. A venous blood sample was taken immediately before induction of anesthesia for measurement of progesterone concentration. MAC was compared with time after delivery and plasma progesterone concentrations by Kendall's rank correlation.Results: There was a positive correlation between MAC and the time after delivery (P