Potential of a Northern Population of Aedes vexans (Diptera: Culicidae) to Transmit Zika Virus
Potential of a Northern Population of Aedes vexans (Diptera: Culicidae) to Transmit Zika Virus
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DOI：
10.1093/jme/tjx087
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发表时间：
2017-09-01
影响因子：
2.1
通讯作者：
Vaughan, Jefferson A.
中科院分区：
文献类型：
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作者：
O'Donnell, Kyle L.;Bixby, Mckenzie A.;Vaughan, Jefferson A.
寨卡病毒是西半球一种新出现的人类虫媒病毒。由于它有可能传播到新的地理区域，因此确定本地蚊子的媒介能力非常重要。对来自明尼苏达州西北部和北达科他州东北部阿加西湖平原的刺面伊蚊（Meigen）进行媒介能力检测。以埃及伊蚊为阳性对照。给蚊子喂食含有寨卡病毒的血液，两周后对其进行病毒感染和传播检测。环状伊蚊（n = 60）对中肠感染敏感（感染率28%），但对中肠逃逸屏障有一定限制（传播率3%）。钴铁Ae。埃及伊蚊（n = 22）中肠感染率（61%）和传播率（22%）明显较高。为了测试病毒传播，给蚊子接种病毒，16-17天后，测试它们将病毒传播到充满液体的毛细血管中的能力。出乎意料的是，伊蚊的传播率要高得多。（34%, n = 47）；埃及伊蚊（5%,n = 22）。伊蚊的整体传播潜力。传播寨卡病毒的几率为1%。由于其广泛的地理分布，通常极其丰富，和侵略性的人类咬人活动，伊蚊。在北纬地区，刺鼻虫可能成为寨卡病毒的潜在媒介。埃及伊蚊和伊蚊。白纹伊蚊无法存活然而，寨卡病毒是一种灵长类病毒，人类是北纬地区唯一能扩增的宿主物种。作为寨卡病毒的载体，伊蚊。维克斯人必须不断以人类为食。定义Ae的倾向性。反复以人类为食的涡虫将是了解其作为寨卡病毒潜在载体的作用的关键。
Zika virus is an emerging arbovirus of humans in the western hemisphere. With its potential spread into new geographical areas, it is important to define the vector competence of native mosquito species. We tested the vector competency of Aedes vexans (Meigen) from the Lake Agassiz Plain of northwestern Minnesota and northeastern North Dakota. Aedes aegypti (L.) was used as a positive control for comparison. Mosquitoes were fed blood containing Zika virus and 2 wk later were tested for viral infection and dissemination. Aedes vexans (n = 60) were susceptible tomidgut infection (28% infection rate) but displayed a fairly restrictive midgut escape barrier (3% dissemination rate). Cofed Ae. aegypti (n = 22) displayed significantly higher rates of midgut infection (61%) and dissemination (22%). To test virus transmission, mosquitoes were inoculated with virus and 16-17 d later, tested for their ability to transmit virus into fluid-filled capillary tubes. Unexpectedly, the transmission rate was significantly higher for Ae. vexans (34%, n = 47) than for Ae. aegypti (5%, n = 22). The overall transmission potential for Ae. vexans to transmit Zika virus was 1%. Because of its wide geographic distribution, often extreme abundance, and aggressive human biting activity, Ae. vexans could serve as a potential vector for Zika virus in northern latitudes where the conventional vectors, Ae. aegypti and Ae. albopictus Skuse, cannot survive. However, Zika virus is a primate virus and humans are the only amplifying host species in northern latitudes. To serve as a vector of Zika virus, Ae. vexans must feed repeatedly on humans. Defining the propensity of Ae. vexans to feed repeatedly on humans will be key to understanding its role as a potential vector of Zika virus.