Pyrrolizidine alkaloids and bisabolane sesquiterpenes from the roots of Ligularia cymbulifera
Pyrrolizidine alkaloids and bisabolane sesquiterpenes from the roots of Ligularia cymbulifera
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DOI：
10.1002/hlca.200890036
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发表时间：
2008-01-01
影响因子：
1.8
通讯作者：
Gao, Kan
中科院分区：
文献类型：
--
作者：
Liu, Chun-Mei;Wang, He-Xiang;Gao, Kan
从紫草Ligularia cymbuifera Hand.-Mazz中分离得到新的吡咯里西丁生物碱苷1和3个新的高氧双苯并环倍半萜4-6，以及两个已知的吡咯里西丁生物碱2和3，其结构经波谱分析，特别是1D和2D-核磁共振数据得到确证。测定了化合物1、2和4-6对肝癌(BEL-7402)、人白血病(HL-60)、人卵巢癌(HO-8910)和鼻咽癌(KB)细胞株的细胞毒活性(表1-3)。化合物6对BEL-7402细胞有微弱的生长抑制作用。
The new pyrrolizidine alkaloid glycoside 1, and the three new highly oxygenated bisabolane sesquiterpenes 4-6, together with the two known pyrrolizidine alkaloids 2 and 3, were isolated from the roots of Ligularia cymbulifera (W. W SMITH) HAND.-MAZZ. Their structures were established on the basis of spectroscopic analysis, especially 1D- and 2D-NMR data. ne cytotoxic activities of compounds 1, 2, and 4-6 were evaluated against hepatoma (BEL-7402), human leukemia (HL-60), human ovarian carcinoma (HO-8910), and nasopharyngeal carcinoma (KB) cell lines (Tables 1-3). Compound 6 showed weak cell-growth inhibition of BEL-7402 cell.