In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
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DOI：
10.1016/j.visres.2005.08.014
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发表时间：
2005-12-01
期刊：
影响因子：
1.8
通讯作者：
Tonagel, F
中科院分区：
文献类型：
--
作者：
Seeliger, MW;Beck, SC;Tonagel, F
扫描-激光眼底镜检查是一种对活体眼睛进行共聚焦成像的技术。利用不同波长的激光，由于其反射和透射特性，可以获得有关特定组织和层的信息。此外，在蓝色和红外范围内可激发的荧光染料提供了与每层相关的血管结构的独特途径。在动物模型中，在组织特异性启动子的控制下，GFP的表达可以进一步增强特异性。重要的应用领域是视网膜变性的研究和治疗干预的随访。(c) 2005 Elsevier Ltd版权所有。
Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo. The use of lasers of different wavelengths allows to obtain information about specific tissues and layers due to their reflection and transmission characteristics. In addition, fluorescent dyes excitable in the blue and infrared range offer a unique access to the vascular structures associated with each layer. In animal models, a further enhancement in specificity can be obtained by GFP expression under control of tissue-specific promotors. Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention. (c) 2005 Elsevier Ltd. All rights reserved.