Laboratory diagnosis of lupus inhibitors: a comparison of the tissue thromboplastin inhibition procedure with a new platelet neutralization procedure.
Laboratory diagnosis of lupus inhibitors: a comparison of the tissue thromboplastin inhibition procedure with a new platelet neutralization procedure.
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狼疮抑制剂的实验室诊断：组织凝血活酶抑制程序与新的血小板中和程序的比较。
DOI：
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发表时间：
1983
影响因子：
3.5
通讯作者：
J. Schaeffer
中科院分区：
文献类型：
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作者：
D. Triplett;J. Brandt;D. Kaczor;J. Schaeffer
引入活化部分凝血活酶时间（APTT）作为筛选试验已导致循环抗凝剂的识别增加。最常见的抑制剂是狼疮型抗凝血剂。然而，分化这种抑制剂的标准尚未建立。我们评估了两种方法的能力，组织凝血活素抑制（TTI）和一种新的血小板中和程序（PNP），以区分不同类型的凝血抑制剂。广泛用于狼疮抗凝剂诊断的TTI被证明是非特异性的。PNP特异性地从因子VIII、X和V抑制剂中分离狼疮型抑制剂。PNP可能是诊断狼疮抗凝剂的有用测试。
The introduction of the activated partial thromboplastin time (APTT) as a screening test has resulted in increased recognition of circulating anticoagulants. The most frequently encountered inhibitor is the lupus-type anticoagulant. However, criteria for differentiation of this inhibitor are not well-established. We evaluated the ability of two procedures, tissue thromboplastin inhibition (TTI) and a new platelet neutralization procedure (PNP), to differentiate between various types of coagulation inhibitors. The TTI, widely used for the diagnosis of lupus anticoagulants, proved to be nonspecific. The PNP specifically separated lupus-type inhibitors from Factor VIII, X, and V inhibitors. The PNP may be a useful test for the diagnosis of lupus anticoagulants.