Molecular biology of somatostatin receptors.
Molecular biology of somatostatin receptors.
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DOI：
10.1210/edrv-16-4-427
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发表时间：
1995-08
影响因子：
20.3
通讯作者：
T. Reisine;G. Bell
中科院分区：
文献类型：
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作者：
T. Reisine;G. Bell
SOMATOSTATIN[生长激素释放抑制因子（somatotropin release- inhibitory factor， SRIF）]是一种由14个氨基酸组成的多肽，广泛分布于中枢神经系统和外周组织（Ref. 1; review in Ref. 2-4）。它能有效抑制各种内分泌和外分泌细胞的基础和刺激分泌，并作为中枢神经系统的神经递质/神经调节剂，对运动活动和认知功能有影响（1-12）。生长抑素还具有抗增殖作用，可能是细胞增殖和分化的重要激素调节剂（参考文献13-15，并在参考文献16中进行了综述）。生长抑素类活性的第一个证据来自于1968年报道的Krulich等人的研究（17），他们在寻找GHRF时描述了下丘脑提取物中抑制培养中垂体前叶生长激素分泌的一个因子。基于这种抑制活性的鉴定，Krulich等人（17）提出生长激素的分泌是有调控的。
I. Introduction SOMATOSTATIN [somatotropin release-inhibiting factor (SRIF)] is a 14-amino acid polypeptide that is widely distributed throughout the central nervous system and peripheral tissues (Ref. 1; reviewed in Refs. 2–4). It potently inhibits basal and stimulated secretion from a wide variety of endocrine and exocrine cells and functions as a neurotransmitter/neuromodulator in the central nervous system with effects on locomotor activity and cognitive functions (1–12). Somatostatin also has antiproliferative effects and may be an important hormonal regulator of cell proliferation and differentiation (Refs. 13–15 and reviewed in Ref. 16). The first evidence for somatostatin-like activity came from studies of Krulich et al. (17), reported in 1968, who while looking for GHRF described a factor in hypothalamic extracts that inhibited GH secretion from anterior pituitaries in culture. Based on the identification of this inhibitory activity, Krulich et al. (17) proposed that the secretion of GH was regul...