Pot, Atom, and Step Economic (PASE) Synthesis of Highly Substituted Piperidines: A Five-Component Condensation
Pot, Atom, and Step Economic (PASE) Synthesis of Highly Substituted Piperidines: A Five-Component Condensation
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DOI：
10.1055/s-0028-1083182
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发表时间：
2008-11-03
影响因子：
2.6
通讯作者：
Whitwood, Adrian C.
中科院分区：
文献类型：
--
作者：
Clarke, Paul A.;Zaytsev, Andrey V.;Whitwood, Adrian C.
报道了非对映选择性锅-原子-分步经济合成高官能化哌啶的方法。该过程简单地涉及在氯化铟（III）的存在下将乙酰乙酸甲酯、两当量的醛和两当量的苯胺混合在一起。在大多数情况下，哌啶从溶液中沉淀出来。
The diastereoselective pot, atom, and step economic (PASE) synthesis of highly functionalized piperidines is reported. The procedure simply involves mixing methyl acetoacetate, two equivalents of aldehyde and two equivalents of aniline together in the presence of indium(III) chloride. In most cases the piperidine precipitates out of solution.