Four-year longitudinal performance of a population-based sample of healthy children on a neuropsychological battery: the NIH MRI study of normal brain development.
Four-year longitudinal performance of a population-based sample of healthy children on a neuropsychological battery: the NIH MRI study of normal brain development.
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DOI：
10.1017/s1355617711001536
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发表时间：
2012-03
期刊：
影响因子：
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通讯作者：
Brain Development Cooperative Group
中科院分区：
文献类型：
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作者：
Waber DP;Forbes PW;Almli CR;Blood EA;Brain Development Cooperative Group
美国国立卫生研究院（NIH）正常大脑发育的磁共振成像（MRI）研究是一项具有里程碑意义的研究，在以人群为基础的健康儿童样本中，从出生到成年早期，纵向跟踪了大脑的结构和代谢发育和行为。神经心理学测试的横断面结果已经在之前被描述过。本报告详细介绍了基线时6至18岁儿童（N=383）的4年纵向神经心理结果，其中219人（57.2%）完成了所有3次就诊。主要观察结果是：(1)在相同的测量方法中，个体儿童在每次访问中表现出相当大的分数差异；(2)收入相关的纵向差异比横断面数据更突出；(3)认知和行为测量与体重指数无相关性；(4)尽管两次访问间隔为2年，但仍有几项措施显示出实践效果。这些数据提供了一个无与伦比的机会来观察一套标准和常用的神经心理学测量方法在健康儿童人群样本中的规范性表现和随时间的变化。因此，它们为在研究环境和临床实践中使用和解释这些仪器提供了重要的背景。
The National Institutes of Health (NIH) Magnetic Resonance Imaging (MRI) Study of Normal Brain Development is a landmark study in which structural and metabolic brain development and behavior are followed longitudinally from birth to young adulthood in a population-based sample of healthy children. Cross-sectional findings from the neuropsychological test battery have been previously described. The present report details 4-year longitudinal neuropsychological outcomes for those children who were aged 6 to 18 years at baseline (N=383), of whom 219 (57.2%) completed all 3 visits. Primary observations were (1) individual children displayed considerable variation in scores across visits on the same measures; (2) income-related differences were more prominent in the longitudinal than in the cross-sectional data; (3) no association between cognitive and behavioral measures and body mass index; and (4) several measures showed practice effects, despite the 2-year interval between visits. These data offer an unparalleled opportunity to observe normative performance and change over time on a set of standard and commonly used neuropsychological measures in a population-based sample of healthy children. They thus provide important background for the use and interpretation of these instruments in both research settings and clinical practice.