Tailored supramolecular gel and microemulsion crystallization strategies - is isoniazid really monomorphic?
Tailored supramolecular gel and microemulsion crystallization strategies - is isoniazid really monomorphic?
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DOI：
10.1039/c8ce00066b
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发表时间：
2018-03-14
期刊：
影响因子：
3.1
通讯作者：
Steed, Jonathan W.
中科院分区：
文献类型：
--
作者：
Kennedy, Stuart R.;Jones, Christopher D.;Steed, Jonathan W.
我们报告了超分子凝胶和微乳液液滴结晶方法在异烟肼结晶中的应用。定制的胶凝因子已被设计为具有异烟肼模拟功能，试图控制晶体形态和多晶型行为。研究了微乳液结晶以实现药物结晶的热力学控制。这两种技术都只产生了一种形式的异烟肼，这意味着它是真正的单晶型。
We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morphology and polymorphic behaviour. Microemulsion crystallisation was investigated to achieve thermodynamic control over drug crystallisation. Both techniques resulted in only a single form of isoniazid implying that it is genuinely monomorphic.