Impact of bacterial sRNAs in stress responses.
Impact of bacterial sRNAs in stress responses.
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DOI：
10.1042/bst20160363
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发表时间：
2017-12-15
影响因子：
3.9
通讯作者：
Wagner EGH
中科院分区：
文献类型：
--
作者：
Holmqvist E;Wagner EGH
细菌的生活是严酷的，涉及许多被视为压力的环境和内部挑战。因此，足够的反应，以生存，科普，并抵消压力条件已经发展。在过去的几十年里，一类小的非编码RNA（sRNA）已被证明是参与应激反应的关键参与者。这篇综述将主要从肠道细菌的角度讨论涉及反义型sRNAs的应激反应途径。这些主题包括细菌如何处理严重的包膜压力，DNA损伤的威胁，有毒糖中间体引起的中毒问题，铁稳态问题和营养限制/饥饿。讨论的例子强调了如何缓解压力，以及sRNA如何在调节回路中起作用。对于某些情况下，我们将提出的方案，可能会建议为什么从转录后控制的sRNA的贡献，而不是单独的转录控制，似乎是一个有益的和普遍选择的功能。
Bacterial life is harsh and involves numerous environmental and internal challenges that are perceived as stresses. Consequently, adequate responses to survive, cope with, and counteract stress conditions have evolved. In the last few decades, a class of small, non-coding RNAs (sRNAs) has been shown to be involved as key players in stress responses. This review will discuss — primarily from an enterobacterial perspective — selected stress response pathways that involve antisense-type sRNAs. These include themes of how bacteria deal with severe envelope stress, threats of DNA damage, problems with poisoning due to toxic sugar intermediates, issues of iron homeostasis, and nutrient limitation/starvation. The examples discussed highlight how stress relief can be achieved, and how sRNAs act mechanistically in regulatory circuits. For some cases, we will propose scenarios that may suggest why contributions from post-transcriptional control by sRNAs, rather than transcriptional control alone, appear to be a beneficial and universally selected feature.