Hypertension and peripheral insulin resistance. Possible mediating role of intracellular free magnesium.
Hypertension and peripheral insulin resistance. Possible mediating role of intracellular free magnesium.
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DOI：
10.1093/ajh/3.5.373
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发表时间：
1990-05
影响因子：
3.2
通讯作者：
L. Resnick;R. Gupta;H. Gruenspan;M. Alderman;J. Laragh
中科院分区：
文献类型：
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作者：
L. Resnick;R. Gupta;H. Gruenspan;M. Alderman;J. Laragh
为探讨高血压与胰岛素抵抗之间的关系，我们利用31P-核磁共振波谱对正常血压(n=20)和高血压病患者(n=20)口服100g葡萄糖负荷后红细胞内游离镁水平(MGIF)进行了无创检测。与正常血压组相比，高血压组的空腹血糖和胰岛素水平相似，但对葡萄糖的综合胰岛素反应高45%(312+/-13.4v215+/-7.5microU/mL，P<0.001)。高血压组MGIF水平显著降低(183+/-9vs251+/-9mumol/L，P<0.001)，且与收缩压(r=-0.77，P<0.001)、舒张压(r=-0.81，P<0.001)及胰岛素综合反应(r=-0.72，P<0.001)密切负相关。此外，虽然胰岛素反应也与潜在的收缩压(r=0.69，P<.001)和舒张压(r=.73，P<.001)有关，但当根据Mgif水平进行调整后，这些关系不再显著。我们推测，高血压和外周胰岛素抵抗可能是常见的异常细胞内离子环境的不同临床表现，至少部分特征是细胞内游离镁水平受到抑制。
To investigate the association of hypertension and insulin resistance, we utilized 31P-NMR spectroscopy to noninvasively assess intracellular free magnesium levels (Mgif) in erythrocytes of normotensive (n = 20) and essential hypertensive (n = 20) subjects given an oral 100 g glucose load. In hypertensive compared with normotensive subjects, fasting glucose and insulin levels were similar, but the integrated insulinemic responses to glucose were 45% greater (312 +/- 13.4 v 215 +/- 7.5 microU/mL, P less than .001). In hypertension, Mgif levels were significantly reduced (183 +/- 9 v 251 +/- 9 mumol/L, P less than .001), and for all subjects were closely and inversely related to systolic (r = -0.77, P less than .001) and diastolic (r = -0.81, P less than .001) blood pressures, and to the integrated insulin response (r = -0.72, P less than .001). Furthermore, while insulin responses were also related to the underlying systolic (r = 0.69, P less than .001) and diastolic (r = .73, P less than .001) pressures, these relations were no longer significant when adjusted for Mgif levels. We hypothesize that hypertension and peripheral insulin resistance may be different clinical expressions of a common abnormal intracellular ionic environment, characterized at least in part by suppressed levels of intracellular free magnesium.