PRIMATE SPINOTHALAMIC PATHWAYS .3. THALAMIC TERMINATIONS OF THE DORSOLATERAL AND VENTRAL SPINOTHALAMIC PATHWAYS
PRIMATE SPINOTHALAMIC PATHWAYS .3. THALAMIC TERMINATIONS OF THE DORSOLATERAL AND VENTRAL SPINOTHALAMIC PATHWAYS
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DOI：
10.1002/cne.902880309
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发表时间：
1989-10-15
影响因子：
2.5
通讯作者：
HODGE, CJ
中科院分区：
文献类型：
--
作者：
APKARIAN, AV;HODGE, CJ
用辣根过氧化物酶从灵长类动物腰髓顺行运输的方法，确定了脊髓丘脑背外侧通路和腹侧通路的终末位置。一只动物没有脊髓损伤，而在另外两只动物中，一只接受了中胸背外侧索损伤，另一只接受了注射对侧的胸中腹侧象限损伤。无脊髓损伤的动物丘脑标记明显小于两种脊髓损伤动物的标记。此外，在有脊椎损伤的动物身上。丘脑内可见HRP标记细胞。因此，其余6只动物接受了同侧半横断和双侧背柱损伤，而不考虑对侧损伤。没有对侧损害的动物的丘脑标记被认为代表了脊髓丘脑到间脑的总输入。在这些动物中，LABEL主要定位于膝状体上核和枕部，腹后外侧核的尾侧和口部，腹后下核的外侧半部分和未定带，而在丘脑内侧，LABEL主要位于内侧背核和中央外侧核的后背部两条不同的带上。在其他丘脑核团中也发现了散在的浅色标记。在腹侧后外侧观察到的终末标记图案呈片状排列，而在丘脑其他部位观察到更均匀的标记图案。观察丘脑标记模式。对侧腹侧象限损伤的动物的丘脑标记代表DSTT的终止，而对侧背侧索部损伤的动物的丘脑标记代表VSTT的终止。这两组之间的标记模式相似。然而，他们之间有很小的差异。这些结果表明DSTT和VSTT的终末在很大程度上重叠并支配丘脑的外侧和内侧。
The termination sites of the dorsolateral (DSTT) and ventral (VSTT) spinothalamic pathways were determined by using anterograde transport of horseradish peroxidase from the lumbar spinal cord in primates. One animal had no spinal cord lesions, while of two other animals, one received a midthoracic dorsolateral funiculus lesion, and the other received a midthroacic ventral quadrant lesion contralateral to the injection. The thalamic label in the animal with no spinal cord lesion was much less than the label in the two animals with spinal lesions. Moreover, in the animals with spinal lesions. HRP-labeled cells were found within the thalamus. Therefore, the remaining six animals received ipsilateral hemisections and bilateral dorsal column lesions, irrespective of the contralateral lesions. The thalamic label in the animals without contralateral lesions were assumed to represent the total spinothalamic input to the diencephalon. In these animals, label was located mainly in suprageniculate and pulvinar oralis, caudal and oral divisions of ventral posterior lateral nucleus, the lateral half of ventral posterior inferior nucleus, and zona incerta, while in the medial thalamus label was primarily in two distinct bands in the medial dorsal nucleus and in the posterior dorsal portion of central lateral nucleus. Scattered lighter labeling was found in other thalamic nuclei. The pattern of terminal labeling observed in the ventral posterior lateral region was arranged in patches, while elsewhere in the thalamus a more uniform labelling pattern was observed. The thalamic labeling pattern was observed. The thalamic label in animals with contralateral ventral quadrant lesions represented the terminations of the DSTT, while the label in animals with contralateral dorsolateral funiculus lesions represented VSTT terminations. The labelling pattern was similar between these two groups. However, there were small differences betwen them. These results indicate that DSTT and VSTT terminations largely overlap and innervate the lateral and medial thalamus.