CD73 mediates adhesion of B cells to follicular dendritic cells
CD73 mediates adhesion of B cells to follicular dendritic cells
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DOI：
10.1182/blood.v88.5.1755.bloodjournal8851755
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发表时间：
1996-09-01
期刊：
影响因子：
20.3
通讯作者：
Jalkanen, S
中科院分区：
文献类型：
--
作者：
Airas, L;Jalkanen, S
淋巴细胞-血管粘附蛋白-2最近被鉴定为CD 73。CD 73分子，也称为外-5 '-核苷酸酶，是一种淋巴细胞成熟标志物，参与细胞内信号传导以及淋巴细胞增殖和活化。CD 73除了介导淋巴细胞与内皮细胞的结合外，还介导B细胞与滤泡树突状细胞（FDC）之间的粘附，作为抗CD 73的单克隆抗体（MoAb）在体外抑制分离的生发中心B细胞与FDC的聚集。分离的生发中心细胞的细胞离心制备和不同扁桃体B细胞群的双色免疫荧光染色显示，CD 73在FDC和小的、再循环的IgD（+）B细胞上表达，但仅在生发中心内的少数B细胞上表达。因此，我们认为FDC上的CD 73在控制生发中心的B细胞-FDC相互作用和B细胞成熟中具有重要作用。(C)1996年，美国血液学会。
Lymphocyte-vascular adhesion protein-2 was recently identified as CD73. The CD73 molecule, otherwise known as ecto-5'-nucleotidase, is a lymphocyte maturation marker that is involved in intracellular signaling, and lymphocyte proliferation and activation. We now show that CD73, in addition to mediating lymphocyte binding to endothelial cells, also mediates adhesion between B cells and follicular dendritic cells (FDC), as a monoclonal antibody (MoAb) against CD73 inhibited the aggregation of isolated germinal center B cells and FDC in vitro. Cytocentrifuge preparations of isolated germinal center cells and two-color immunofluorescence stainings of different tonsillar B-cell populations show that CD73 is expressed on FDC and on small, recirculating IgD(+) B cells, but only on a few B cells inside the germinal center, Thus, we propose that CD73 on FDC has an important role in controlling B cell-FDC interactions and B-cell maturation in germinal centers. (C) 1996 by The American Society of Hematology.