Neocortical dynamics at multiple scales: EEG standing waves, statistical mechanics, and physical analogs
Neocortical dynamics at multiple scales: EEG standing waves, statistical mechanics, and physical analogs
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DOI：
10.1016/j.mbs.2010.12.003
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发表时间：
2011-02-01
影响因子：
4.3
通讯作者：
Nunez, Paul L.
中科院分区：
文献类型：
--
作者：
Ingber, Lester;Nunez, Paul L.
头皮电位（EEG）的动态行为显然是由于一些全球和本地的过程与重要的自上而下和自下而上的相互作用跨空间尺度的组合。在治疗全球机制，我们强调的重要性，有髓轴突的传播延迟和周期性的边界条件，在皮质白质系统，这是拓扑接近一个球壳。相比之下，建议的本地机制是多尺度之间的相互作用，通过短距离的无髓鞘纤维皮质柱。一个力学模型，包括一个拉伸的字符串与附加的非线性弹簧演示的一般思想。弦产生的驻波类似于在某些大脑状态下观察到的大规模相干EEG。附加的弹簧类似于较小的（介观）尺度的柱状动力学。一般来说，我们期望在所有尺度上的弦位移和EEG结果从全局和局部现象。新皮层相互作用的统计力学（SMNI）计算与典型EEG一致的振荡行为，在列内，通过短程无髓鞘纤维在相邻列之间，通过有髓鞘纤维跨皮层区域，并且还导出与全局EEG模型一致的弦方程。(C)2010年爱思唯尔公司All rights reserved.
The dynamic behavior of scalp potentials (EEG) is apparently due to some combination of global and local processes with important top-down and bottom-up interactions across spatial scales. In treating global mechanisms, we stress the importance of myelinated axon propagation delays and periodic boundary conditions in the cortical-white matter system, which is topologically close to a spherical shell. By contrast, the proposed local mechanisms are multiscale interactions between cortical columns via short-ranged non-myelinated fibers. A mechanical model consisting of a stretched string with attached nonlinear springs demonstrates the general idea. The string produces standing waves analogous to large-scale coherent EEG observed in some brain states. The attached springs are analogous to the smaller (mesoscopic) scale columnar dynamics. Generally, we expect string displacement and EEG at all scales to result from both global and local phenomena. A statistical mechanics of neocortical interactions (SMNI) calculates oscillatory behavior consistent with typical EEG, within columns, between neighboring columns via short-ranged non-myelinated fibers, across cortical regions via myelinated fibers, and also derives a string equation consistent with the global EEG model. (C) 2010 Elsevier Inc. All rights reserved.