Depth-dependent temporal response properties in core auditory cortex.
Depth-dependent temporal response properties in core auditory cortex.
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核心听觉皮层的深度依赖性时间响应特性。
DOI：
10.1523/jneurosci.2863-11.2011
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发表时间：
2011-09-07
期刊：
影响因子：
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通讯作者：
Linden JF
中科院分区：
文献类型：
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作者：
Christianson GB;Sahani M;Linden JF
听觉皮层内皮层层的计算作用已被证明是难以确定的。一种假设是，层间皮层处理可能专门用于分析声音的时间特性；如果是这样，那么皮层对刺激发生的时间背景的敏感性应该存在系统性的深度依赖变化。我们同时记录了CBA/Ca小鼠的初级听觉皮层和前听场皮层深度的神经反应，发现在缓慢（1-10次/s）的噪声突发序列中，对第二次和以后的噪声突发的反应有系统的深度依赖性。在所有深度，列车内对噪声突发的响应通常随列车速度的增加而降低；然而，随着列车速率的增加，越浅层的滚降速度越快。此外，在一些来自中层到浅层的记录中，对3-4次脉冲/s列车的噪声爆发的反应比对较慢列车的噪声爆发的反应更强烈。这种与列车速度的非单调性在前听觉的更浅层中尤为明显，在这里，对慢速列车背景下的噪音爆发的反应有时甚至比对列车开始时的噪音爆发的反应更强烈。这些发现可能反映了刺激后皮层活动抑制和恢复的深度依赖性，我们认为这可能是由于前馈突触和循环突触突触抑制的层状差异。
The computational role of cortical layers within auditory cortex has proven difficult to establish. One hypothesis is that interlaminar cortical processing might be dedicated to analyzing temporal properties of sounds; if so, then there should be systematic depth-dependent changes in cortical sensitivity to the temporal context in which a stimulus occurs. We recorded neural responses simultaneously across cortical depth in primary auditory cortex and anterior auditory field of CBA/Ca mice, and found systematic depth dependencies in responses to second-and-later noise bursts in slow (1–10 bursts/s) trains of noise bursts. At all depths, responses to noise bursts within a train usually decreased with increasing train rate; however, the rolloff with increasing train rate occurred at faster rates in more superficial layers. Moreover, in some recordings from mid-to-superficial layers, responses to noise bursts within a 3–4 bursts/s train were stronger than responses to noise bursts in slower trains. This non-monotonicity with train rate was especially pronounced in more superficial layers of the anterior auditory field, where responses to noise bursts within the context of a slow train were sometimes even stronger than responses to the noise burst at train onset. These findings may reflect depth dependence in suppression and recovery of cortical activity following a stimulus, which we suggest could arise from laminar differences in synaptic depression at feedforward and recurrent synapses.