Metabolic Syndrome Is Associated with Intracranial Large Artery Disease among Ethnic Chinese Patients with Stroke
Metabolic Syndrome Is Associated with Intracranial Large Artery Disease among Ethnic Chinese Patients with Stroke
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DOI：
10.1016/j.jstrokecerebrovasdis.2009.01.010
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发表时间：
2009-11-01
影响因子：
2.5
通讯作者：
Wong, Meng-Cheong
中科院分区：
文献类型：
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作者：
De Silva, Deidre Anne;Woon, Fung-Peng;Wong, Meng-Cheong
背景资料：代谢综合征（MetS）和颅内大动脉疾病（ICLAD）的相关性已被描述，但仅在朝鲜族卒中患者队列中。我们调查了中国少数民族患者MetS和ICLAD的关系。方法：这是一项对居住在新加坡的中国急性缺血性卒中患者进行的前瞻性研究。经颅彩色多普勒或磁共振血管造影诊断为ICLAD。结果：在研究的135例患者中，ICLAD患者的Mets频率较高（39% nu 16%，P = 0.003）。这种关联与年龄、高血压和糖尿病（P = .003）以及个体MetS标准（P = .004）无关。ICLAD的患病率与满足MetS标准的数量呈正相关（P = 0.021）。结论：我们在中国卒中患者中MetS和ICLAD之间的相关性研究结果与朝鲜族患者的结果一致。该验证为进一步研究MetS和ICLAD之间的病理生理学联系提供了基础。
Background: The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients. Methods: This is a prospective study of consecutive ethnic Chinese patients with acute ischemic stroke living in Singapore. ICLAD was diagnosed on transcranial color-coded Doppler or magnetic resonance angiography. Results: Among the 135 patients studied, the frequency of Mets was higher among patients with ICLAD (39% nu 16%, P = .003). This association was independent of age, hypertension, and diabetes (P = .003), and individual MetS criteria (P = .004). The prevalence of ICLAD positively correlated with the number of MetS criteria fulfilled (P = .021). Conclusions: Our findings of an association between MetS and ICLAD among ethnic Chinese patients with stroke concur with findings among ethnic Korean patients. This validation provides a basis for further investigation into the pathophysiologic link between MetS and ICLAD.