Observations on the Relation Between Ventricular Activation Sequence and the Hemodynamic State
Observations on the Relation Between Ventricular Activation Sequence and the Hemodynamic State
复制标题
心室激动序列与血流动力学状态关系的观察
作者：
J. .. Abildskov;R. Eich;K. Harumi;H. Smulyan
血流动力学参数包括记录左、右心室压、主动脉压、左心室压曲线一阶导数和颈动脉流量，并记录不同的心室激活模式。采用特殊的措施来实现心房在不同心室激活模式的心室充盈中的可比作用。在完整的心脏传导系统中，血流动力学参数的明确但微小的差异与不同的激活模式有关。与异常激活相比，正常心室激活产生的两个心室的峰值压力和颈动脉流量略高。每种不同的激活模式与心室压力曲线的详细形状和左右心室压力上升的相对开始时间的差异有关。当特化传导系统被大剂量的瓦巴因阻断时，各种心室激活模式与血流动力学参数的显著差异有关。这些发现可以解释之前发表的相互矛盾的结果。他们还表明，传导系统的疾病可能在心脏病中起着重要的功能作用。
Hemodynamic parameters including records of left and right ventricular pressure, aortic pressure, the first derivative of the left ventricular pressure curve, and carotid flow were recorded with different patterns of ventricular activation. Special measures were used to achieve a comparable role of the atrium in ventricular filling with the different ventricular activation patterns. With an intact cardiac conduction system, definite but small differences in the hemodynamic parameters named were associated with different activation patterns. Normal ventricular activation produced slightly higher peak pressures in both ventricles and higher carotid flow than did abnormal activation. Each different activation pattern was associated with differences in the detailed shape of the ventricular pressure curves and with differences in the relative time of onset of pressure rise in right and left ventricles. When the specialized conduction system was blocked with large doses of ouabain, various patterns of ventricular activation were associated with marked differences of the hemodynamic parameters named. These findings may explain previously published conflicting results. They also suggest that disease of the conduction system may have a significant functional role in cardiac disease.