Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage
Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage
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DOI：
10.1136/oem.2006.029124
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Chonan, T.
中科院分区：
文献类型：
--
作者：
Hamaguchi, T.;Omae, K.;Chonan, T.
目的：确定铟对肺的影响，并评估铟暴露与肺影响之间的暴露-效应和暴露-反应关系。方法：对四家ITO制造或ITO回收厂的93名男性铟暴露工人和93名男性未暴露工人进行了横断面研究。测定血清铟（in - s）作为生物暴露指标。暴露工人的in - s几何平均值（GSD）为8.25 ng/ml(4.55)，未暴露工人为0.25 ng/ml（2.64）。In-S最高浓度为116.9 ng/ml。以呼吸症状和工作史问卷、肺活量测定、胸部高分辨率计算机断层扫描（HRCT）、血清KL-6、血清SP-A、血清SP-D和血清CRP作为疗效指标。结果：肺量测定、主观症状和肺间质或肺气肿变化的患病率在暴露和非暴露工人之间没有差异。暴露工人的KL-6、SP-D和SP-A的几何平均（GSD）分别为495.4 U/ml（2.26）、85.2 ng/ml（2.02）和39.6 ng/ml(1.57)，显著高于未暴露工人。暴露和未暴露工人的KL-6 （41.9 vs 2.2）、SP-D （39.8 vs 7.5）和SP-A （43.0 vs 24.7）超过参考值的患病率（%）也显著高于正常值。将暴露工人按In-S划分为7组，发现In-S与KL-6、In-S与SP-D之间存在非常明显的暴露效应和暴露反应关系。结论：基于血清免疫化学生物标志物和HRCT的研究结果表明，暴露于难溶性铟化合物粉尘可能存在肺间质性损伤的风险。
Objectives: To identify the effects of indium on the lung and to assess exposure-effect and exposure-response relations between indium exposure and effects on the lungs.Methods: Ninety three male indium exposed and 93 male non-exposed workers from four ITO manufacturing or ITO recycling plants were analysed in a cross-sectional study. Indium in serum (In-S) was determined as a biological exposure index. Geometric means (GSD) of In-S were 8.25 ng/ml (4.55) in the exposed workers and 0.25 (2.64) in the non-exposed workers. The maximum concentration of In-S was 116.9 ng/ml. A questionnaire for respiratory symptoms and job histories, spirometry, high-resolution computerised tomography (HRCT) of the chest, serum KL-6, serum SP-A, serum SP-D and serum CRP were measured as the effect indices.Results: Spirometry, subjective symptoms and the prevalence of interstitial or emphysematous changes on lung HRCT showed no differences between exposed and non-exposed workers. Geometric means (GSD) of KL-6, SP-D and SP-A in the exposed workers were 495.4 U/ml (2.26), 85.2 ng/ml (2.02) and 39.6 ng/ml (1.57), and were significantly higher than those in the non-exposed workers. The prevalence (%) of the exposed and nonexposed workers exceeding the reference values were also significantly higher in KL-6 (41.9 vs 2.2), SP-D (39.8 vs 7.5), and SP-A (43.0 vs 24.7). Very sharp exposure-effect and exposure-response relations were discovered between In-S and KL-6 and between In-S and SP-D when the exposed workers were classified into seven groups by In-S.Conclusions: The study outcomes with regard to the basis of serum immunochemistry biomarkers and HRCT indicate that exposure to hardly soluble indium compound dust may represent a risk for interstitial lung damage.