CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
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DOI：
10.1016/j.celrep.2020.108101
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发表时间：
2020-09-08
期刊：
影响因子：
8.8
通讯作者：
Zou, Yan
中科院分区：
文献类型：
--
作者：
Feng, Zhigang;Zhao, Yupeng;Zou, Yan
树突形态发生是神经元建立其感受野所必需的，因此也是神经系统正常运作的解剖学基础。调控树枝晶分支的分子机制还不完全清楚。利用线虫中的多树突状PVD神经元，我们确定CatP-8/P5A ATPase是树突分支的关键调节因子，控制DMA-1受体向内质网(ER)的移位。DMA-1的特异性信号肽和CatP-8的ATPase活性在这一过程中是必不可少的。我们的结果表明，P5A-ATPase可能调节内质网中的蛋白质转位。
Dendrite morphogenesis is essential for a neuron to establish its receptive field and is, thus, the anatomical basis for the proper functioning of the nervous system. The molecular mechanisms governing dendrite branching are not fully understood. Using the multi-dendritic PVD neuron in the nematode Caenorhabditis elegans, we identify CATP-8/P5A ATPase as a key regulator of dendrite branching that controls the translocation of the DMA-1 receptor to the endoplasmic reticulum (ER). The specific signal peptide of DMA-1 and the ATPase activity of CATP-8 are essential for this process. Our results reveal that P5A ATPase may regulate protein translocation in the ER.