Angiotensin receptor blocker improves a stress-induced prothrombotic state in a murine model.
Angiotensin receptor blocker improves a stress-induced prothrombotic state in a murine model.
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血管紧张素受体阻滞剂可改善小鼠模型中应激诱导的血栓前状态。
DOI：
10.1097/mbc.0000000000000451
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Murohara T.
中科院分区：
文献类型：
--
作者：
Hayashi M;Takeshita K;Uchida Y;Yamamoto K;Matsushita T;Murohara T.
越来越多的证据表明，心理压力与血栓性疾病以及高血压之间存在着很强的因果关系[1]。由于血栓形成与高血压在病因学上有很大的重叠性，应激相关疾病将成为预防高血压患者血栓形成的潜在治疗靶点，血管紧张素II拮抗剂厄贝沙坦是基于分子模拟的对CC趋化因子受体2（CCR 2）具有较高亲和力的抗高血压药物，并通过核因子κ B（NF κ B）途径抑制单核细胞趋化蛋白-1（MCP-1）的产生[2]。ACTIVE-I试验表明厄贝沙坦治疗可能减少高血压患者的血栓栓塞事件[3]。虽然预期厄贝沙坦对凝血和纤溶系统发挥有益作用，但认为其与降压作用无关，但尚未确定厄贝沙坦是否改善应激诱导的血栓前状态。
Accumulating evidence has demonstrated that a strong causal link exists between psychological stress and thrombotic diseases as well as hypertension [1]. Because of substantial overlap between thrombosis and hypertension in etiology, stress-related disorders would be a potential therapeutic target in the prevention of thrombosis in hypertensive patients.The angiotensin II antagonist irbesartan is the antihypertensive drug that possesses higher affinity for CC chemokine receptor type 2 (CCR2) based on molecular modeling, and inhibits monocyte chemoattractant protein-1 (MCP-1) production via the nuclear factorkappa B (NFкB) pathway [2]. The ACTIVE-I trial suggested the possibility that irbesartan treatment reduced thromboembolic events in hypertensive patients [3]. Although it is anticipated that irbesartan exerts beneficial effects on the coagulation and fibrinolytic systems, which are regarded to be independent of blood pressure-lowering action, it has been undetermined whether irbesartan improves the stress-induced prothrombotic state.