Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease:: A two-year follow-up study
Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease:: A two-year follow-up study
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DOI：
10.1002/mds.20855
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发表时间：
2006-07-01
影响因子：
8.6
通讯作者：
Rinne, Juha O.
中科院分区：
文献类型：
--
作者：
Bruck, Anna;Aalto, Sargo;Rinne, Juha O.
31例药物初治的帕金森病(PD)患者在确诊时(基线)和2年后进行了6-[F-18]氟-L-多巴(F-DOPA)正电子发射断层扫描，以了解PD早期纹状体和纹状体外区对F-多巴的摄取。24名健康对照组接受了一次F-多巴PET扫描。用统计参数图和自动感兴趣区分析纹状体和纹状体外区的区域差异。我们的研究表明，未经药物治疗的早期帕金森病患者的F-多巴摄取在尾壳核的背侧最严重，但在整个纹状体与对照组相比明显减少。在帕金森病的第一年，纹状体的F-多巴摄取呈进行性区域性下降，尾壳核的背侧仍是受影响最严重的区域。纹状体亚区之间的绝对下降是相等的。这表明，多巴胺功能的下降始于背尾壳核，但一旦开始，纹状体各亚区的进展速度是相等的。与纹状体的下降相反，至少在帕金森病的最初几年，皮质F-多巴摄取增加是普遍的。(C)2006年运动无序协会。
Thirty-one drug-naive patients with Parkinson's disease (PD) underwent 6-[F-18]fluoro-L-dopa (F-dopa) positron emission tomography (PET) scan at the time of the diagnosis (baseline) and 2 years later in order to investigate F-dopa uptake in striatal and extrastriatal regions during the first years of early PD. Twenty-four healthy controls underwent one F-dopa PET scan. The regional differences in the striatal and extrastriatal regions were analyzed with statistical parametric mapping and automated region of interest analyses. Our study shows that the F-dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls. During the first years of PD, there is a progressive regional decline in striatal F-dopa uptake, the dorsal part of caudal putamen being still the most severely affected region. The absolute decline is equal between the striatal subregions. This suggests that the decline of dopamine function starts from the dorsocaudal putamen, but once started, the rate of progression is equal between the subregions of the striatum. In contrast to the striatal decline, the increased cortical F-dopa uptake prevails at least during the first years of PD. (C) 2006 Movement Disorder Society.