Imaging of Site Specific Bone Turnover in Osteoporosis Using Positron Emission Tomography
Imaging of Site Specific Bone Turnover in Osteoporosis Using Positron Emission Tomography
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DOI：
10.1007/s11914-014-0231-2
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发表时间：
2014-12-01
影响因子：
4.3
通讯作者：
Fogelman, Ignac
中科院分区：
文献类型：
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作者：
Blake, Glen M.;Siddique, Musib;Fogelman, Ignac
动态氟-18标记氟化钠正电子发射断层扫描（F-18-NaF PET）的功能成像技术允许通过测量骨骼中任何部位的氟化物到骨的血浆清除率来定量评估局部骨形成。F-18-NaF PET为研究髋关节和脊柱以及纯皮质骨或松质骨区域的特定部位骨形成提供了一种新颖的非侵入性方法。该技术补充了传统的测量骨转换使用生化标志物和骨活检作为一种工具，以研究新的治疗骨质疏松症，并持有作为治疗效果的早期生物标志物在临床试验中的未来作用的承诺。本文综述了获取和分析F-18-NaF PET扫描数据的方法，并概述了一种简化的方法，该方法使用5分钟静态PET扫描图像结合静脉血样本来估计单次注射示踪剂时骨骼多个部位的F-18-NaF血浆清除率。
The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography (F-18-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. F-18-NaF PET provides a novel and noninvasive method of studying site-specific bone formation at the hip and spine, as well as areas of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers and bone biopsy as a tool to investigate new treatments for osteoporosis, and holds promise of a future role as an early biomarker of treatment efficacy in clinical trials. This article reviews methods of acquiring and analyzing F-18-NaF PET scan data, and outlines a simplified approach that uses 5-minute static PET scan images combined with venous blood samples to estimate F-18-NaF plasma clearance at multiple sites in the skeleton with a single injection of tracer.