The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections-A Single Center Cohort
The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections-A Single Center Cohort
复制标题
DOI：
10.1097/inf.0000000000002291
复制
发表时间：
2019-07-01
影响因子：
3.6
通讯作者：
Nir-Paz, Ran
中科院分区：
文献类型：
--
作者：
Gordon, Oren;Oster, Yonatan;Nir-Paz, Ran
背景资料：肺炎支原体（MP）是学龄儿童社区获得性上呼吸道和下呼吸道感染的主要原因;然而，越来越多的人认识到，年幼的儿童也会受到影响。临床表现从无症状到严重的复杂性肺炎，有时伴有肺外表现。方法：我们回顾了哈大沙-希伯来大学医学中心收治的所有MP阳性儿科患者的病历。如果2007年至2017年发送的口咽拭子的MP聚合酶链反应为阳性，则定义为MP阳性病例。结果：在研究期间，我们确定了353例MP阳性儿科病例，其中51.3%（181/353）小于6岁。353例患者中有332例（94%）获得了完整的临床数据。中位年龄为5.7岁（范围：3周至18岁）。疾病的表现不同，年龄较小和较大的儿童。6岁以上的儿童更有可能有胸片证实的肺炎（66% vs. 52%; P = 0.009），而年幼的儿童更有可能有其他呼吸道表现（37% vs. 25%; P = 0.017）。然而，住院时间和儿科重症监护室入院率在年龄组之间没有差异。肺外表现的发生率也相似。结论：MP相关感染是儿科人群（包括年幼儿童）住院的重要原因（
Background: Mycoplasma pneumoniae (MP) is a major cause of community-acquired upper and lower respiratory infections in school-age children; however, there is increasing recognition that younger children are also affected. Clinical manifestations vary from asymptomatic, to severe complicated pneumonia sometimes with extrapulmonary manifestations. Methods: We reviewed the medical records of all MP positive pediatric patients admitted to the Hadassah-Hebrew University Medical Center. MP positive case was defined if MP polymerase chain reaction was positive from an oropharyngeal swab sent from 2007 to 2017. Results: During the study period, we identified 353 MP positive pediatric cases, of which 51.3% (181 of 353) were younger than 6 years old. Full clinical data were available for 332 of 353 (94%). The median age was 5.7 years (range, 3 weeks to 18 years). Disease presentation differed between younger and older children. Children older than 6 years were more likely to have chest radiograph confirmed pneumonia (66% vs. 52%; P = 0.009), while younger children were more likely to have other respiratory manifestations (37% vs. 25%; P = 0.017). The duration of hospitalization and pediatric intensive care unit admission rate, however, did not differ between age groups. The rate of extrapulmonary manifestations were also similar. Conclusions: MP-associated infection is a significant cause of hospitalization in the pediatric population including younger children (