Cell membranes: The electromagnetic environment and cancer promotion
Cell membranes: The electromagnetic environment and cancer promotion
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DOI：
10.1007/bf00973286
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发表时间：
1988-07
影响因子：
4.4
通讯作者：
W. R. Adey
中科院分区：
文献类型：
--
作者：
W. R. Adey
使用弱电磁场来研究将体液刺激从表面受体位点耦合到细胞内部的事件的序列和能量学已经将细胞膜确定为与这些低频场相互作用的主要位点。细胞表面化学事件的场调制表明与激素、抗体和神经递质与其特异性结合位点的结合相关的初始弱触发物的主要放大。钙离子在这种刺激放大中起着关键作用，可能是通过与表面糖蛋白结合的高度合作改变，改变钙结合在膜表面的传播波。跨越细胞膜的蛋白质颗粒形成信号传导和能量转移的途径。比105 V/cm的膜电位梯度弱数百万倍的场调节细胞对表面刺激分子的反应。证据支持在跨膜信号耦合的关键步骤的非线性，非平衡过程。强大的促进癌症的佛波酯作用于细胞膜，刺激细胞生长和DNA合成所必需的鸟氨酸脱羧酶。这种反应被弱微波场增强，也作用于细胞膜。
Use of weak electromagnetic fields to study the sequence and energetics of events that couple humoral stimuli from surface receptor sites to the cell interior has identified cell membranes as a primary site of interaction, with these low frequency fields. Field modulation of cell surface chemical events indicates a major amplification of initial weak triggers associated with binding of hormones, antibodies and neurotransmitters to their specific binding sites. Calcium ions play a key role in this stimulus amplification, probably through highly cooperative alterations in binding to surface glycoproteins, with spreading waves of altered calcium binding across the membrane surface. Protein particles spanning the cell membrane form pathways for signaling and energy transfer. Fields millions of times weaker than the membrane potential gradient of 105V/cm modulate cell responses to surface stimulating molecules. The evidence supports nonlinear, nonequilibrium processes at critical steps in transmembrane signal coupling. Powerful cancer-promoting phorbol esters act at cell membranes to stimulate ornithine decarboxylase which is essential for cell growth and DNA synthesis. This response is enhanced by weak microwave fields, also acting at cell membranes.