The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy.
The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy.
复制标题
DOI：
--
复制
发表时间：
2013-10
期刊：
影响因子：
2.2
通讯作者：
Anna B Hart;D. Samuels;T. Hulgan
中科院分区：
文献类型：
--
作者：
Anna B Hart;D. Samuels;T. Hulgan
线粒体毒性与一些治疗限制性抗逆转录病毒治疗并发症有关，未经治疗的HIV感染中线粒体功能障碍的报告表明HIV的抗逆转录病毒治疗独立效应。一些研究探讨了mtDNA单倍群（mtDNA多态性模式）与HIV感染和/或抗逆转录病毒治疗结果之间的关系，但结果不一致。我们系统地回顾了已发表的研究，检查HIV感染者的mtDNA单倍型群，总结报告的结果关联，并强调潜在的未来研究方向。我们确定了2005-2013年发表的21篇文章。研究了多种不同的表型;大多数是抗逆转录病毒治疗相关的代谢结果（例如脂肪代谢障碍、胰岛素抵抗和血脂异常）。单倍型H与大多数结局相关，包括艾滋病进展、CD 4 T细胞恢复、肝硬化（丙型肝炎合并感染）和代谢结局。这篇综述是第一篇关注HIV中mtDNA单倍型群的新兴领域，并总结了欧洲和非洲裔人群中mtDNA单倍型群与临床结局之间相关性的已发表文献。一些报道的关联需要复制和理想的生物学验证才能得出明确的结论，但在这方面的研究有可能解释结果的差异和影响患者的临床管理。
Mitochondrial toxicity is implicated in some treatment-limiting antiretroviral therapy complications, and reports of mitochondrial dysfunction in untreated HIV infection suggest antiretroviral therapy independent effects of HIV. Several studies have explored associations between mtDNA haplogroups (patterns of mtDNA polymorphisms) and outcomes of HIV infection and/or antiretroviral therapy, but findings have been inconsistent. We systematically reviewed published studies examining mtDNA haplogroups in HIV-infected persons to summarize reported outcome associations, and to highlight potential future research directions. We identified 21 articles published from 2005-2013. Multiple different phenotypes were studied; most were antiretroviral therapy associated metabolic outcomes (e.g. lipodystrophy, insulin resistance, and dyslipidemia). Haplogroup H was associated with the most outcomes, including AIDS progression, CD4 T-cell recovery, cirrhosis (in hepatitis C coinfection), and metabolic outcomes. This review is the first to focus on the emerging area of mtDNA haplogroups in HIV, and summarizes the published literature on associations between mtDNA haplogroups and clinical outcomes in populations of European and African descent. Several reported associations require replication and ideally biological verification before definitive conclusions can be drawn, but research in this area has the potential to explain outcome disparities and impact clinical management of patients.