Hearing loss and the risk of dementia in later life
Hearing loss and the risk of dementia in later life
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DOI：
10.1016/j.maturitas.2018.03.004
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发表时间：
2018-06-01
期刊：
影响因子：
4.9
通讯作者：
Almeida, Osvaldo P.
中科院分区：
文献类型：
--
作者：
Ford, Andrew H.;Hankey, Graeme J.;Almeida, Osvaldo P.
痴呆症是全球残疾的主要来源，目前没有可用的疾病改善治疗。听力损失可能与老年痴呆症的风险增加有关，因此，考虑到有效干预措施的可用性，听力损失可能是一个可改变的风险因素。我们通过两种互补的方法研究了听力损失和痴呆的相关性：一项前瞻性队列研究，包括37，898名老年男性（平均年龄72.5 ± 4.6岁），平均随访11.1年，以及前瞻性研究的系统回顾和Meta分析。在我们的队列中，听力损失男性比无显著听力损伤的男性更容易患痴呆症（n = 6948，18.3%），调整后的风险比为1.69，95% CI = 1.54-1.85。在我们的综述中，听力障碍患者中痴呆的综合风险为1.49（95%CI 1.30-1.67）（14项纳入研究）。研究质量、持续时间和痴呆类型并没有显著改变结果。我们发现，在我们的新数据和荟萃分析中，伴有听力障碍的痴呆事件的风险增加。这是一个重要的发现，特别是考虑到最近的建议，中年听力损失可能占全球痴呆症病例的9.1%，应继续探索减少其影响的努力。
Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the association of hearing loss and dementia through two complementary approaches: a prospective, cohort study of 37,898 older men (mean age 72.5 +/- 4.6 years) with a mean follow-up of 11.1 years, and a systematic review and meta analysis of prospective studies. In our cohort, men with hearing loss were more likely to develop dementia (n = 6948, 18.3%) than men free of significant hearing impairment adjusted hazard ratio 1.69, 95% CI = 1.54-1.85. In our review, the aggregated hazard of dementia was 1.49 (95% CI 1.30-1.67) in those with hearing impairment (14 included studies). Study quality, duration and dementia type did not alter the results considerably. We found an increased risk of incident dementia with hearing impairment in both our novel data and the meta-analysis. This is an important finding, particularly in light of recent suggestions that mid-life hearing loss may account for up to 9.1% of dementia cases worldwide, and efforts to reduce its impact should continue to be explored.