Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients
Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients
复制标题
DOI：
10.1016/j.clinbiochem.2008.01.027
复制
发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Morsch, Vera M.
中科院分区：
文献类型：
--
作者：
Battisti, Vanessa;Maders, Liesi D. K.;Morsch, Vera M.
目的：探讨急性淋巴细胞白血病（ALL）患者的氧化状态及抗氧化防御机制。设计与方法：测定血浆硫代巴比妥酸活性物质（TBARS）浓度、血清蛋白羰基化、全血过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性，以及血浆和红细胞硫醇水平和血清维生素E浓度。本研究将80例ALL患儿分为4组：刚诊断组、缓解诱导组、缓解维持组和未治疗组。结果：ALL患者的TBARS水平和血清蛋白羰基化水平高于对照组，这些患者的抗氧化剂水平降低。结论：这些发现可能表明抗氧化剂减少与氧化损伤引起的细胞改变水平增加之间可能存在联系，支持急性淋巴细胞白血病中存在持续氧化应激的观点。(c) 2008加拿大临床化学家学会。Elsevier Inc.出版。版权所有。
Objectives: To evaluate the oxidative status and antioxidant defense in patients with acute lymphoblastic leukemia (ALL).Design and methods: We measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasmatic and erythrocyte thiol levels and serum vitamin E concentration. This study was performed on 80 children with ALL divided into 4 groups: just diagnosed, remission induction, remission maintenance and out-of-treatment.Results: TBARS levels and serum protein carbonylation were higher in ALL patients than in controls and reduced levels of antioxidants were found in these patients.Conclusion: These findings may indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistence of oxidative stress in acute lymphoblastic leukemia. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.