Structural and functional features of eukaryotic mRNA untranslated regions
Structural and functional features of eukaryotic mRNA untranslated regions
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DOI：
10.1016/s0378-1119(01)00674-6
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发表时间：
2001-10-03
期刊：
影响因子：
3.5
通讯作者：
Liuni, S
中科院分区：
文献类型：
--
作者：
Pesole, G;Mignone, F;Liuni, S
基因组的非编码部分的关键作用现在被广泛承认。特别是，mRNA非翻译区参与许多转录后调控途径，控制mRNA的定位，稳定性和翻译效率。本文综述了真核生物mRNA非翻译区的主要结构和组成特征，并提供了一些生物信息学分析其功能特征的例子。(C)出版社：Elsevier Science B.V.
The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization. (C) 2001 Published by Elsevier Science B.V.