Osteoradionecrosis of mandible bone in patients with oral cancerassociated factors and treatment outcomes
Osteoradionecrosis of mandible bone in patients with oral cancerassociated factors and treatment outcomes
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DOI：
10.1002/hed.23949
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发表时间：
2016-05-01
影响因子：
2.9
通讯作者：
Liu, Shih-An
中科院分区：
文献类型：
--
作者：
Chen, Jyun-An;Wang, Chen-Chi;Liu, Shih-An
背景：本研究的目的是在一大批口腔癌患者中调查与下颌骨放射性骨坏死（ORN）相关的因素。方法回顾性分析口腔癌患者的病历资料，并对发生下颌骨ORN的患者进行鉴定。比较两组患者的变量，并采用logistic回归模型分析相关因素。结果本组共纳入1692例患者，其中105例（6.2%）发生下颌骨ORN。原发部位，包括口底、颊黏膜、磨牙后三角区或牙龈、节段性下颌切除术和原发部位的总辐射剂量75 Gy是与ORN相关的独立因素。经积极治疗，有/无高压氧手术干预后，93.3%的患者完全愈合。结论在口腔癌放疗后患者中，ORN是一种少见且可怕的并发症。识别相关因素可以帮助医生识别那些有风险的人。(c) 2015 Wiley期刊公司中国机械工程学报（英文版），2016
BackgroundThe purpose of this study was to investigate factors associated with osteoradionecrosis (ORN) of the mandible bone in a large cohort of patients with oral cancer.MethodsWe reviewed the medical records of patients with oral cancer and identified those with ORN of the mandible bone. Variables of patients with and without ORN were compared and associated factors were investigated by logistic regression model.ResultsA total of 1692 patients were included in the final analysis and 105 patients (6.2%) developed ORN in the mandible bone. Primary site, including mouth floor, buccal mucosa, retromolar trigone, or gum, segmental mandibulectomy, and total radiation dose to the primary site 75 Gy were independent factors associated with ORN. After aggressive treatment using surgical intervention with/without hyperbaric oxygen, 93.3% of the patients healed completely.ConclusionAmong patients with oral cancer after radiation, ORN is an uncommon and dreaded complication. Recognition of associated factors can help physicians to identify those at risk. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 762-768, 2016