Segmental Intracellular, Interstitial, and Intravascular Volume Changes during Simulated Hemorrhage and Resuscitation: A Case Study.
Segmental Intracellular, Interstitial, and Intravascular Volume Changes during Simulated Hemorrhage and Resuscitation: A Case Study.
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DOI：
10.2478/joeb-2019-0006
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发表时间：
2019-01
影响因子：
--
通讯作者：
Loughry M
中科院分区：
文献类型：
--
作者：
Montgomery LD;Montgomery RW;Gerth WA;Bodo M;Stewart JM;Loughry M
本文介绍了一种新的组合阻抗体积描记（IPG）和电生物阻抗谱（BIS）仪器和软件，将允许无创实时测量节段性血流，细胞内，间质和血管内容量的变化，在各种液体管理程序。阻抗装置可作为固定频率IPG运行，用于定量节段性血流和血液动力学，或作为多频BIS运行，用于记录40个离散输入频率下的细胞内和细胞外电阻。然后对细胞外体积进行去卷积，以获得其作为经过时间的函数的血管内和间质组分体积。本文的目的是描述这种仪器，并证明可以获得的信息，通过使用它来监测节段性室容积反应的猪模型在模拟出血和复苏。这些信息可能在体液平衡的快速变化的诊断和管理以及各种临床治疗中证明是有价值的。
This paper describes a new combined impedance plethysmographic (IPG) and electrical bioimpedance spectroscopic (BIS) instrument and software that will allow noninvasive real-time measurement of segmental blood flow, intracellular, interstitial, and intravascular volume changes during various fluid management procedures. The impedance device can be operated either as a fixed frequency IPG for the quantification of segmental blood flow and hemodynamics or as a multi-frequency BIS for the recording of intracellular and extracellular resistances at 40 discrete input frequencies. The extracellular volume is then deconvoluted to obtain its intravascular and interstitial component volumes as functions of elapsed time. The purpose of this paper is to describe this instrumentation and to demonstrate the information that can be obtained by using it to monitor segmental compartment volume responses of a pig model during simulated hemorrhage and resuscitation. Such information may prove valuable in the diagnosis and management of rapid changes in the body fluid balance and various clinical treatments.