THE INSPIRE BIO-RESOURCE RESEARCH PLATFORM FOR HEALTHY AGING AND GEROSCIENCE: FOCUS ON THE HUMAN TRANSLATIONAL RESEARCH COHORT (THE INSPIRE-T COHORT)
THE INSPIRE BIO-RESOURCE RESEARCH PLATFORM FOR HEALTHY AGING AND GEROSCIENCE: FOCUS ON THE HUMAN TRANSLATIONAL RESEARCH COHORT (THE INSPIRE-T COHORT)
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DOI：
10.14283/jfa.2020.38
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发表时间：
2020-07-10
影响因子：
3.9
通讯作者：
Vellas, B.
中科院分区：
文献类型：
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作者：
Guyonnet, S.;Rolland, Y.;Vellas, B.
老年科学领域关注衰老的核心生物学机制，涉及与年龄有关的疾病的发病，以及导致依赖性的内在能力（IC）（身体功能）的下降。更好地了解如何测量个人的真实年龄或生物衰老是一个必要的步骤，它可能导致能够预测健康衰老的假定标记物的定义。预防健康衰老和医学振兴研究所（INSPIRE）平台倡议的主要目标是建立一个从动物模型到人类和医疗保健系统的老年科学和健康衰老研究项目。INSPIRE人类转化队列（INSPIRE- t队列）的具体目的是收集临床、数字和成像数据，并进行相关和广泛的生物银行，以便对人类进行基础和转化研究。方法INSPIRE-T队列是一项人口研究，包括1000名来自法国图卢兹及周边地区的不同年龄（20岁或以上-年龄没有上限）和功能水平（从健壮到虚弱，甚至依赖）的个体，随访超过10年。每年在研究机构或在家中根据标准化程序收集各种数据。在两次年度访问之间，通过使用与世卫组织合作开发的ICOPE监测应用程序，每4个月监测一次IC域。一旦确认IC下降，参与者将进行临床评估和血液采样，以调查在检测到IC下降时的衰老标记。生物标本包括血液、尿液、唾液和牙菌斑，在基线时收集，然后每年收集一次。每两年在一个大的亚组受试者中收集鼻咽拭子和皮肤表面样本。在基线访问时收集粪便、毛球和皮肤活检，并将在纵向随访期间再次进行。招聘于2019年10月开始，预计持续两年。在INSPIRE-T队列中收集和探索的生物资源将提供给学术和行业合作伙伴，旨在确定衰老、年龄相关疾病和IC进化的强大（一组）标记物，这些标记物可能是药理学或非药理学靶向的。INSPIRE-T还将致力于开发一种综合方法，探索创新技术的使用和一种新的、功能和以人为本的卫生保健途径，以促进健康老龄化。
Background The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging. Objectives The main objective of the INStitute for Prevention healthy aging and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans. Methods The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over - no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up. Expected Results Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a new, function and person-centered health care pathway that will promote a healthy aging.