Acquisition of iron from host proteins by the group A Streptococcus
Acquisition of iron from host proteins by the group A Streptococcus
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DOI：
10.1128/iai.64.12.5428-5429.1996
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发表时间：
1996-12-01
影响因子：
3.1
通讯作者：
Scott, JR
中科院分区：
文献类型：
--
作者：
Eichenbaum, Z;Muller, E;Scott, JR
为了确定哺乳动物铁结合蛋白，可以作为化脓性链球菌，A组链球菌（GAS）的铁源，我们使用了平板测定。铁蛋白、氯化血红素、血红蛋白、肌红蛋白和过氧化氢酶可以支持GAS在缺铁培养基上的生长。然而，当铁作为铁饱和转铁蛋白或乳铁蛋白提供或与细胞色素c结合时，未检测到生长。因此，GAS似乎可以利用人体内可用的细胞内铁源，这与其在感染期间引起组织破坏的能力一致。
To identify mammalian iron-binding proteins that can serve as iron sources for Streptococcas pyogenes, the group A streptococcus (GAS), we used a plate assay. Ferritin, hemin, hemoglobin, myoglobin, and catalase can support growth of GAS on iron-depleted medium. However, growth was not detected when iron was provided as iron-saturated transferrin or lactoferrin or bound to cytochrome c. Therefore, it appears that GAS can use the intracellular iron sources available in the human body, which is consistent with its ability to cause tissue destruction during infection.